Biological Science Faculty Member
Dr. Hank W. Bass
- Office: 3074 King Life Sciences
- Office: (850) 644-9711
- Lab: King Life Sciences
- Lab: (850) 644-8058
- Fax: (850) 645-8447
- Mail code: 4295
- E-mail: email@example.com
Ph.D., North Carolina State University, 1992.
Graduate Faculty Status
Working model of chromatin signatures from nuclease sensitivity profiling using
DNS (Differential Nuclease Sensitivity) mapping, from Vera et al., 2014.
Hop meiotic prophase chromosomes and telomeres, from KA Easterling:
Research and Professional Interests:
Our work makes use of maize (corn, Zea mays L.) to define structure-function relationships of heredity and gene regulation across multiple scales. We employ genetics, microscopy, molecular biology, and genomics technologies.
Current research is advancing in several related areas, including:
Meiotic Chromosome Behavior
- Meiotic telomeres, nuclear envelope SUN-domain, LINC complex proteins in chromosome segregation
- Meiotic chromosome behavior in hop
Epigenomics and chromatin structure
- Development of genome-wide nuclease sensitivity and open chromatin profiling technologies for plants
- Analysis of genome-wide DNA damage signaling pathways in maize and human
- Spatiotemporal mapping of DNA replication in nuclei from a naturally developing multicellular organism
- G-quadruplex (G4) DNA in maize as potential regulatory motifs for plant energy stress
(2018) Easterling KA, Pitra NJ, Jones RJ, Lopes LG, Aquino JR, Dong Z, Matthews PD, and Bass HW. "3D Molecular Cytology of Hop (Humulus lupulus) Meiotic Chromosomes Reveals Non-disomic Pairing and Segregation, Aneuploidy, and Genomic Structural Variation." Frontiers in Plant Science 9:1501(13pp) (doi /10.3389/fpls.2018.01501).
(2018) Turpin ZM, Vera DL, Savadel SD, Lung, P-Y, Wear EE, Mickelson-Young L, Thompson, WF, Hanley-Bowdoin L, Dennis, JH, Zhang J, and Bass, HW. "Chromatin Structure Profile Data from DNS-seq: Differential Nuclease Sensitivity Mapping of Four Reference Tissues of B73 Maize (Zea mays L)."Data in Brief August 2018 (DOI: 10.1016/j.dib.2018.08.015).
(2018) Springer NM, et al. "The maize W22 genome provides a foundation for functional genomics and transposon biology"Nature Genetics July 2018 (DOI: 10.1038/s41588-018-0158-0).
(2018) Girimurugan SB, Liu Y, Lung P-Y, Vera DL, Dennis JH, Bass HW, and Zhang "iSeg: an efficient algorithm for segmentation of genomic and epigenomic data." BMC Bioinformatics 19:131(15pp) (DOI: 10.1186/s12859-018-2140-3).
(2018) Griffin BD and Bass HW. "Review: Plant G-quadruplex (G4) motifs in DNA and RNA; abundant, intriguing sequences of unknown function." Plant Science 269:143-147
(2017) Zhang D, Easterling KA, Pitra NJ, Coles MC, Buckler ES, Bass HW, and Matthews PD. "Non-Mendelian SNP inheritance and atypical meiotic configurations are prevalent in hop (Humulus lupulusL.)" The Plant Genome 10(3):(14 pp). (DOI: 10.3835/plantgenome2017.04.0032).
(2017) Savadel SD and Bass HW. "Take a Look at Plant DNA Replication: Recent Insights and New Questions." Plant Signaling & Behavior, 12:4, e1311437.
(2016) Rodgers-Melnick E, Vera DL, Bass HW, and Buckler ES. "Open Chromatin Reveals the Functional Maize Genome." Proc Nat Acad Sci, USA 113(22):E3177-E3184.
(2015) Bass HW, Hoffman GG, Lee T-J, Wear EE, Joseph SR, Allen GC, Hanley-Bowdoin L, and Thompson WF. "Defining multiple, distinct, and shared spatiotemporal patterns of DNA replication and endoreduplication from 3D image analysis of developing maize (Zea mays L.) root tip nuclei." Plant Molecular Biology 89(4):339-351. [PubMed 26394866]
(2015) Kopylov M, Bass HW, and Stroupe ME. "The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA" Biochemistry 54(9):1743-1757.
(2014) Vera DL, Madzima TF, Labonne JD, Alam MP, Hoffman GG, Girimurugan SB, Zhang J, McGinnis KM, Dennis JH, and Bass HW. "Differential nuclease sensitivity profiling of chromatin reveals biochemical footprints coupled to gene expression and functional DNA elements in maize." Plant Cell 26(10):3883-3893.
(2014) Andorf CM, Kopylov MS, Dobbs D, Koch KE, Stroupe ME, Lawrence CJ, and Bass HW. "G-quadruplex motifs in maize (Zea mays L.) occupy specific sites in thousands of genes coupled to energy status, hypoxia, low sugar, and nutrient deprivation" J Genetics Genomics 41(12):627-647.
(2014) Murphy SP, Gumber HK, Mao YY, and Bass HW. "A dynamic meiotic SUN belt includes the zygotene-stage telomere bouquet and is disrupted in chromosome segregation mutants of maize (Zea mays L.)." Frontiers in Plant Science 5:314.
(2014) Bass HW, Wear EE, Lee T-J, Hoffman GG, Gumber HK, Allen GC, Thompson WF, Hanley-Bowdoin L. "A maize root tip system to study DNA replication programmes in somatic and endocycling nuclei during plant development" J Exp Botany 65:2747-2756.
(complete list of publications page: http://fla.st/2G6ax5K)
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