Structural Biology and Molecular Biophysics
P. Bryant Chase
Biomechanics of cardiac and skeletal muscle.
Jonathan H. Dennis
The biology of chromatin involved in the innate immune response.
Debra A. Fadool
Structure and Function of Ion Channel Proteins; Signal Transduction and Neuromodulation by Phosphorylation; Impact of Obesity and Diabetes mellitus on Olfactory and Sensory Processes
Muscle contraction; structure-function of proteins; cellular physiology.
Dynamic changes in chromatin and chromosome architecture regulates patterns of cellular gene expression during differentiation and development, or in response to environmental signals. Our research looks at various levels of chromatin, chromosome and nuclear structure, from individual nucleosome modifications to the dynamic 3D structure of chromosomes and their inter-relationships in the nucleus and how they affect genome functions.
Biological membranes; cell-substrate interactions; bionanotechnology.
M. Elizabeth Stroupe
The Stroupe laboratory uses cryogenic electron microscopy and X-ray crystallography to discover fundamental mechanisms in ribosome biogenesis and sulfur metabolism.
Paul Q. Trombley
Olfaction; synaptic physiology and plasticity; ion channel modulation.
Kenneth A. Taylor
Macromolecular structure determination by 3-D electron microscopy; muscle, cytoskeleton and cell adhesion structure; virus structure.
Dr. Qian Yin
Biochemist and structural biologist dedicated to delineate individual proteins functions and their interactions in innate immunity, inflammation, pathogen-host interaction, and autophagy.
Kaposi's sarcoma-associated herpesvirus (KSHV); viral evasion of the host innate immune responses; viral modulation of the host kinase signaling pathways; role and assembly of KSHV tegument proteins.
The primary research focus of this group is the elucidation of the 3-dimensional structures, functional properties, and assemblages of biological macromolecules using biophysical techniques (e.g. X-ray crystallography, cryoelectron microscopy, electron diffraction, computational modeling, EPR and NMR spectroscopy). This research effort is part of the interdepartmental Structural Biology Program, which is based in the Institute of Molecular Biophysics. Additional research areas of faculty in this group include radiation biology, NMR imaging & cellular diffusion measurements, membrane biophysics, and molecular/cell biology. Students have access to a variety of superb research facilities housed in the Institute of Molecular Biophysics, Department of Biological Science, and the nearby National High Magnetic Field Laboratory.Graduate training in Structural Biology also is available through the Molecular Biophysics Program