Developmental Biology and Gene Expression
My laboratory takes a novel and innovative approach to studying colorectal cancer by combining latest advances in cancer genomics with classical Drosophila genetics and high-throughput drug screening.
Hank W. Bass
Telomeres, meiosis, and chromatin structure in maize through genetics, genomics, and 3D molecular cytology.
Brian P. Chadwick
X chromosome inactivation; chromatin organization; epigenetic gene regulation.
Cell fate specification and reprogramming in plants; evolutionary and developmental biology; plant-environment interaction; genomics and epigenomics; proteomics; molecular genetics.
Intercellular communication in Drosophila egg chambers, growth and proliferation control and cancer models, cell competition.
Jonathan H. Dennis
The biology of chromatin involved in the innate immune response.
James M. Fadool
Developmental biology; cellular and genetic analysis of visual system development.
Epigenetic regulation of neuropsychiatric disorders.
Structure and replication of chromosomes in stem cells and cancer.
Genotype-to-phenotype mapping, evolution and development, evolutionary and population genetics.
Kathryn M. Jones
Rhizobial/plant symbiotic interactions.
Thomas C.S. Keller
Cell and molecular biology of the cytoskeleton; cytoskeleton regulation and energetics.
Karen M. McGinnis
Molecular genetics; genomics; epigenetic regulation of gene expression in plants.
M. Elizabeth Stroupe
3-D electron microscopy and x-ray crystallography of protein complexes involved in mRNA and sulfur metabolism.
Virus-host cell interactions; Cell biology of HCV replication; Cellular co-factors for HIV and HCV infection.
Our research focuses on the molecular bases of gene function and processes that control development. We use classical, modern, and unique model systems to analyze the mechanistic bases of gene expression and regulation, establish relationships between the structure and function of gene products, and investigate how organisms integrate multiple signals during development. Well-staffed core facilities in the Department of Biological Science, close work with associated departments/programs (e.g. Chemistry Department, the Institute of Molecular Biophysics, the National High Magnetic Field Laboratory), and new initiatives in computational biology and medical sciences afford access to state-of-the-art research technologies. In addition to emphasizing day-to-day interactions between students and faculty advisors, joint lab meetings and topical seminar series allow faculty and students to present and critique the latest research. Our small but highly productive laboratories provide excellent breadth and balance in graduate and postgraduate training while emphasizing high-quality, nationally competitive research.