Biological Science Faculty Member
Dr. Paul Q. Trombley
- Office: 207 Biomedical Research Facility
- Office: (850) 644-1614
- Lab: Biomedical Research Facility
- Lab: (850) 644-1616
- Fax: (850) 644-0989
- Mail code: 4340
- E-mail: email@example.com
Ph.D., University of Oregon, 1990
Graduate Faculty Status
Research and Professional Interests:
The primary research goal of our laboratory is to understand the cellular and molecular mechanisms that regulate neuronal excitability and the efficacy of synaptic transmission. Our experimental approach uses primary neuronal culture, brain slices, and patch-clamp electrophysiology, in combination with molecular biology and histological techniques, to examine modulation of ion channels, neurotransmitter receptors, and synaptic circuits. One of our current projects involves determining the cellular and molecular basis of circadian rhythms in the olfactory system. We are exploring how electrical synapses formed by gap junctions and rhythmic expression of monoamine neurotransmitters (norepinephrine, dopamine, serotonin, and melatonin) contribute to rhythmic regulation of synaptic circuits underlying odor information processing. Other projects include investigating the role of zinc as a neuromodulator and the function of circuits of the hippocampus, hypothalamus, and amygdala.
Corthell, J. T., D. A. Fadool, and P. Q. Trombley. 2012, Diurnal rhythms in connexin and AMPA receptor expression in the rat olfactory bulb. Neuroscience 222:38–48.
Trombley, P. Q., L. J. Blakemore, and B. J. Hill. 2011. Zinc modulation of glycine receptors. Neuroscience 186:32–38.
Davila, N. G., T. A. Houpt, and P. Q. Trombley. 2007. Expression and function of kainate receptors in the rat olfactory bulb. Synapse 61:320–334.
Blakemore, L. J., C. W. Levenson, and P. Q. Trombley. 2006. Neuropeptide Y modulates excitatory synaptic transmission in the olfactory bulb. Neuroscience 138:663–674.
Blakemore, L. J., M. Resasco, M. A. Mercado, and P. Q. Trombley. 2006. Evidence for calcium-permeable AMPA receptors in the olfactory bulb. American journal of Physiology—Cell Physiology 290:C925–C935.
Horning, M. S., B. Kwon, L. J. Blakemore, C. M. Spencer, M. Goltz, T. A. Houpt, and P. Q. Trombley. 2004. AMPA receptor subunit expression in rat olfactory bulb. Neuroscience Letters 372:230–234.
Blakemore, L. J., and P. Q. Trombley. 2004. Diverse modulation of olfactory bulb AMPA receptors by zinc. NeuroReport 15:919–923.
Blakemore, L. J., and P. Q. Trombley. 2003. Kinetic variability of AMPA receptors among olfactory bulb neurons in culture. NeuroReport 14:965–970.
Davila, N. G., L. J. Blakemore, and P. Q. Trombley. 2003. Dopamine modulates synaptic transmission between rat olfactory bulb neurons in culture. Journal of Neurophysiology 90:395–404.
Graduate Students:Korshunov, Kirill
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