Biological Science Faculty Member
Dr. Karen M. McGinnis
- Office: 2019 King Life Sciences
- Office: (850) 645-8814
- Lab: King Life Sciences
- Lab: (850) 645-8815
- Fax: (850) 645-8447
- Mail code: 4295
- E-mail: email@example.com
Ph.D., Arizona State University, 2000
Graduate Faculty Status
Dr. Karen McGinnis is currently recruiting new postdoctoral investigators.
Research and Professional Interests:
My long term goal is to understand how identical genomic sequences can be interpreted to cause distinct expression patterns and phenotypes. I am particularly interested in the regulation of epigenetic modifications that heritably alter the expression of endogenous and transgenic loci in plants. These phenomena have been shown to be key elements in the growth, development, and gene regulation of a broad range of organisms; I study them predominantly in maize.
(McGinnis Lab authors in bold print below)
Huang, J., J. Zheng, H. Yuan, and K. McGinnis (2018) Distinct tissue-specific transcriptional regulation revealed by gene regulatory networks in maize.. BMC Plant Biology 18: 14 pp.
Li, Q., J. I. Gent, G. Zynda, J. Song, I. Makarevitch, C. D. Hirsch, C. N. Hirsch, R. K. Dawe, T. Madzima, K. M. McGinnis, D. Lisch, R. J. Schmitz, M. W. Vaughn, and N. M. Springer (2015) RNA-directed DNA methylation enforces boundaries between heterochromatin and euchromatin in the maize genome. Proceedings of the National Academy of Sciences of the United States of America 112: 14728-14733.
(Full text) (PDF)
Madzima, T., J. Huang, and K. M. McGinnis (2014) Chromatin structure and gene expression changes associated with loss of MOP1 activity in Zea mays. Epigenetics 9: 1047-1059.
Madzima, T. F., A. E. Sloan, L. Stroud, and K. M. McGinnis 2014 Chapter 9: Epigenomics In Genetics, Genomics and Breeding of Maize
(Available from CRC Press)
Sloan, A. E., L. Sidorenko, and K. M. McGinnis (2014) Diverse Gene Silencing Mechanisms with Distinct Requirements for RNA Polymerase Subunits in Zea mays. Genetics 198: .
(Full text online) (PDF online)
Haag, J. R., B. Brower-Toland, , E. K. Krieger, L. Sidorenko, C. D. Nicora, A. Norbeck, A. Irsigler, H. LaRue, J. Brzeski, K. McGinnis, S. Ivashuta, L. Pasa-Tolic, V. L. Chandler, and C. S. Pikaard (2014) Functional Diversification of Maize RNA Polymerase IV and V Subtypes via Alternative Catalytic Subunits. Cell Reports 9: 378-390.
Vera, D. L., J. Labonne, P. Alam, T. Madzima, G. G. Hoffman, S. B. Gigimurugan, J. Zhang, K. M. McGinnis, J. H. Dennis, and H. W. Bass, (2014) Differential nuclease sensitivity profiling of chromatin reveals biochemical footprints coupled to gene expression and functional DNA elements in maize. Plant Cell In press: .
Li, Q., S. R. Eichten, P. J. Hermanson, V. Zaunbrecher, J. Song, J. Wendt, H. Rosenbaum, T. F. Madzima, A. E. Sloan, J. Huang, D. Burgess, T. Richmond, S. M. Kaeppler, K. M. McGinnis, R. Meeley, O. Danilevskaya, M. W. Vaughn, J. Jeddeloh, and N. M. Springer (2014) Genetic Perturbation of the Maize Methylome. The Plant Cell 26: 4602-4616.
(Full text) (PDF)
Gent, J. I., T. F. Madzima, R. Bader, M. R. Kent, X. Zhang, M. Stam, K. M. McGinnis, and R. K. Dawe (2014) Accessible DNA and relative depletion of H3K9me2 at maize RdDM loci. The Plant Cell .
Labonne, J. D., J. E. Dorweiler, and K. M. McGinnis (2013) Changes in nucleosome position at transcriptional start sites of specific genes in Zea mays mediator of paramutation1 mutants. Epigenetics 8: 398-408.
Fincher, J., D. Vera, D. D. Hughes, K. M. McGinnis, J. H. Dennis, and H. W. Bass (2013) Genome-wide prediction of nucleosome occupancy in maize (Zea mays L.) reveals plant chromatin structural features at genes and other elements at multiple scales. Plant Physiology 162: 1127-41.
Boerner, S. L., and K. M. McGinnis (2012) Computational Identification and Functional Predictions of Long Noncoding RNA in Zea mays. PLoS One 7: e43047.
Eichten, S. E., N. A. Ellis, I. Makarevitsch, C. Yeh, J. I. Gent, L. Guo, K. M. McGinnis, X. Zhang, P. S. Schnable, M. W. Vaughn, R. K. Dawe, and N. M. Springer (2012) Spreading of heterochromatin is limited to specific families of maize retrotransposons. PLoS Genetics 8: e1003127.
Madzima, T. F., E. S. Mills, J. M. Gardiner, and K. M. McGinnis (2011) Identification of epigenetic regulators of a transcriptionally silenced transgene in maize. G3: Genes, Genomes, Genetics 1: 75-83.
Irsigler, A., and K. M. McGinnis 2011 Genetic resources for the study of epigenetic gene regulation in maize. In Epigenetics: A resource manual Jeff Craig and Nick Wong Horizon Press 409-420
McGinnis, K. M. (2010) RNAi for plant functional genomics. Briefings in Functional Genomics and Proteomics doi:10.1093/bfgp/elp052: .
McGinnis, K. M. 2009 Use of transgene induced RNAi to regulate endogenous gene expression. In Methods in Molecular Biology M. Paul Scott Humana Press 91-99
Notice: Uninitialized string offset: 0 in /usr/local/www/apache24/data/faculty.php on line 51
Bowler, C. A., and et al. (2008) The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Nature 456: 239-244.
Barbazuk, W. B., Y. Fu, and K. M. McGinnis (2008) Genome-wide analyses of alternative splicings in plants: opportunities and challenges.. Genome Research 18: 1381-1392.
McGinnis, K. M., N. Murphy, A. Carlson, A. Akula, C. Akula, H. Basinger, M. Carlson, P. Hermanson, N. Kovacevic, M. McGill, V. Seshadri, J. Yoyokie, K. Cone, H. F. Kaeppler, S. M. Kaeppler, and N. M. Springer (2007) Assessing the efficiency of RNA interference for maize functional genomics. Plant Physiology 143: 1441-1451.
McGinnis, K. M., C. Springer, Y. Lin, C. C. Carey, and V. L. Chandler (2006) Transcriptionally silenced transgenes in maize are activated by three mutations defective in paramutation. Genetics 173: 1637-1647.
Alleman, M. A., L. Sidorenko, K. McGinnis, J. White, V. Seshadri, J. Dorweiler, K. Sikkink, and V. Chandler (2006) An RNA-dependent RNA polymerase is required for paramutation in maize. Nature 442: 295-298.
: External sites will open in a new browser window.