Department of Biological Science

Biological Science Faculty Member

Lab Home Page

Professor
Ph.D., Michigan State University, 1992 PostDoc, Harvard University
Graduate Faculty Status

Research and Professional Interests:

Using zebrafish as an model system, we investigate genetic & cellular mechanisms regulating photoreceptor development, patterning, retinal degeneration and regeneration.

Selected Publications:

Zelinka, C. P., M. Sotolongo-Lopez, and J. M. Fadool (2018) Targeted disruption of the endogenous zebrafish rhodopsin locus as models of rapid rod photoreceptor degeneration. Molecular Vision 24: 587-602.
(View Abstract) 

Sotolongo-Lopez, M., K. Alvarez-Delfin, C. J. Saade, D. L. Vera, and J. M. Fadool (2016) Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish. Plos Genetics 12: e1005968.
(View Abstract) 

Saade, C. J., K. Alvarez-Delfin, and J. M. Fadool (2013) Rod photoreceptors protect from cone degeneration-induced retinal remodeling and restore visual responses in zebrafish. J Neurosci 33: 1804-1814.
(View Abstract) 

Morris, A. C., M. A. Forbes-Osborne, L. S. Pillai, and J. M. Fadool (2011) Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci. 52: 2255-2266.
(View Abstract) 

Alvarez-Delfin, K., A. C. Morris, C. D. Snelson, J. T. Gamse, T. Gupta, F. L. Marlow, M. C. Mullins, H. A. Burgess, M. Granato, and J. M. Fadool (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci USA. 106: 2023-2028.
(View abstract) 

Morris, A. C., T. L. Scholz, S. E. Brockerhoff, and J. M. Fadool (2008) Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol. 68: 605-619.
(View abstract) 

Stearns, G., M. Evangelista, J. M. Fadool, and S. E. Brockerhoff (2007) A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish. J Neurosci. 27: 13866-74.
(View abstract) 

Vihtelic, T. S., F. J. M, T. K. A, and H. D. R (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Mol Vision 13: 1083-1100.
(View Abstract) 

Morris, A. C., S. E. H, W. R. O, and F. J. M (2005) Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafish. Invest Ophthalmol Vis Sci. 46: 4762-71.
(View Abstract) 

DeCarvalho, A. C., S. Cappendijk, and J. M. Fadool (2004) Expression of the Pou domain transcription factor, Brn3b in the lateral line and retina of zebrafish. Dev. Dynamics 229: 869-876.
(View abstract) 

Fadool, J. M. (2003) Development of a rod photoreceptor mosaic revealed in transgenic zebrafish. Dev. Biol. 258: 277-290.
(View abstract) 

McCune, A. R., R. C. Fuller, A. A. Aquilina, R. M. Dawley, J. M. Fadool, D. Houle, J. Travis, and A. S. Kondrashov (2002) A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish. Science 296: 2398-401.
(View abstract) 

Fadool, J. M., D. L. Hartl, and J. E. Dowling (1998) Transposition of the mariner element from Drosophila mauritiana in zebrafish (Danio rerio). Proc. Natl. Acad. Sci. USA 95: 5182-5186.
(View abstract) 

Fadool, J. M., S. E. Brockerhoff, G. A. Hyatt, and J. E. Dowling (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev. Genetics 20: 288-295.
(View abstract) 

Graduate Students: