Biological Science Faculty Member
Dr. W. Ross Ellington
- E-mail: email@example.com
Professor Emeritus of Biological Science
Ph.D., University of Rhode Island, 1976
Enzyme structure, function and evolution; comparative biochemistry
Research and Professional Interests:
Over the years I have been interested in cellular energy homeostasis in animals with emphasis on the evolution and physiological roles of a family of enzymes called the phosphagen (guanidino) kinases. These enzymes include the more familiar creatine kinase which plays a critical role in mitigating spatial and temporal mismatches in ATP supply and demand in certain cell types. Our work has benefited from substantive collaborations with a structural biology group as well as several molecular evolution labs.
Bertin, M., S.A. Pomponi, C. Kouhuta, N. Iwasaki, T. Suzuki and W.R. Ellington (2007) Origin of the genes for the isoforms of creatine kinase. Gene 39: 273-282.
Tanaka, K., K. Uda, M. Shimada, K.-I. Takahashi, S. Gamou, W.R. Ellington and T. Suzuki (2007) Evolution of the cytoplasmic and mitochondrial phosphagen kinases unique to annelid groups. Journal of Molecular Evolution 65: 616-625.
Conejo, M., M. Bertin, S.A. Pomponi and W.R. Ellington (2008) The early evolution of phosphagen kinases- Insights from choanoflagellate and poriferan arginine kinases. Journal of Molecular Evolution 66: 11-20.
Uda, K., K. Yamamoto, N. Iwasaki, M. Awai, K. Fujikura, W.R. Ellington and T. Suzuki (2008) Two-domain arginine kinase from the deep-sea clam Calyptogena kaikoi- Evidence of two active domains. Comparative Biochemistry & Physiology B 151: 176-182.
Hoffman, G.G., O. Davulcu, S. Sona and W.R. Ellington (2008) Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase. FEBS Journal (formerly European Journal of Biochemistry) 275: 646-654.
Suzuki, T., K. Uda, M. Adachi, H. Sanada, K. Tanaka, C. Mizuta, K. Ishida and W.R. Ellington (2009) Evolution of the diverse array of phosphagen systems present in annelids. Comparative Biochemistry & Physiology B 152: 60-66.
Bush, J.D., O. Kirillova, S.A. Clark, O. Davulcu, F. Fabiola, Q. Xie, T. Somasundaram, W.R. Ellington and M.S. Chapman (2011) The structure of lombricine kinase: implications for phosphagen kinase conformational changes. Journal of Biological Chemistry 286: 9338-9350.
Hoffman, G.G. and W.R. Ellington (2011) Arginine kinase isoforms in the closest protozoan relative of metazoans. Comparative Biochemistry & Physiology D (Genomics & Proteomics) 6: 171-177.
Uda, K., W.R. Ellington and T. Suzuki (2012) A diverse array of creatine kinase and arginine kinase isoform genes is present in the starlet sea anemone Nematostella vectensis, a cnidarian model system for studying developmental evolution. Gene 497: 214-227.