Students may choose to work with any Department of Biological Science faculty. With permission from the Associate Chair for Graduate Studies, students may also forge collaborative thesis projects between biology faculty and any other faculty at Florida State University.
My laboratory takes a novel and innovative approach to studying colorectal cancer by leveraging sophisticated genetic tools and practical advantages of Drosophila. We build, study and drug-screen Drosophila cancer models that reflect the complexity and diversity of sequenced human tumors.
Meiosis in higher plants; telomere dynamics; molecular cytology; maize chromatin, nuclease sensitivity profiling, G4-DNA, and genome replication. Work primarily on maize.
Biomechanics of cardiac and skeletal muscle.
Cell fate specification and reprogramming in plants; evolutionary and developmental biology; plant-environment interaction; genomics and epigenomics; proteomics; molecular genetics.
The biology of chromatin involved in the innate immune response.
Structure and Function of Ion Channel Proteins; Signal Transduction and Neuromodulation by Phosphorylation; Impact of Obesity and Diabetes mellitus on Olfactory and Sensory Processes
Using zebrafish as an model system, we investigate genetic & cellular mechanisms regulating photoreceptor development, patterning, retinal degeneration and regeneration.
Muscle contraction; structure-function of proteins; cellular physiology.
Epigenetic regulation of neuropsychiatric disorders
Structure-function studies of virus cell biology. We use live-cell imaging and cryo-EM to uncover mechanisms of virus transport, virus disassembly, nuclear pore interactions and virus compartmentalization inside the nucleus of living cells
Dynamic changes in chromatin and chromosome architecture regulates patterns of cellular gene expression during differentiation and development, or in response to environmental signals. Our research looks at various levels of chromatin, chromosome and nuclear structure, from individual nucleosome modifications to the dynamic 3D structure of chromosomes and their inter-relationships in the nucleus and how they affect genome functions.
I study the symbiotic interaction of nitrogen-fixing rhizobial bacteria with legume host plants: 1)How bacteria manipulate their environment during host plant invasion such that the plant not only permits entry, but provides an invasion pathway for them; 2)Why the interactions of specific strains of Sinorhizobium with particular Medicago truncatula plant ecotypes are more productive than others; 3)How plants direct resources to productive symbionts at the expense of unproductive ones (cheaters).
Biological membranes; cell-substrate interactions; bionanotechnology.
We are interested in the molecular and cellular mechanisms through which sleep and the circadian clock affect neural plasticity from drug tolerance to long-term memory. We use Drosophila melanogaster and mice for our research with sleep deprivation.
Epigenetic gene regulation in maize.
Molecular and statistical properties of adaptive evolution.
Research in the Stagg lab is directed towards two tracks: the mechanisms of membrane trafficking, and high-throughput high-resolution cryo-EM. On the biological side, we determine the structure and mechanisms of protein complexes involved in vesicle trafficking pathways. We have determined structures of COPII and clathrin coats as well as other membrane remodeling complexes. On the technical side, we develop experimental and computational methods to improve structure determination by cryo-EM.
Sensory processing, function and organization of neural circuits, imaging brain activity.
The Stroupe laboratory uses cryogenic electron microscopy and X-ray crystallography to discover fundamental mechanisms in ribosome biogenesis and sulfur metabolism.
Virus-host cell interactions; Stem cell-based models for viral infections; Cell biology of flavivirus replication.
Macromolecular structure determination by 3-D electron microscopy; muscle, cytoskeleton and cell adhesion structure; virus structure.
Plant roots are analogous to the animal gut as both are important sites of nutrient acquisition and microbial activity. We use the plant model system, Arabidopsis thaliana, to study the role of innate immunity in establishing a healthy root microbiome. We use a combination of NextGen sequencing, microscopy, and genetics to study the mechanisms required for distinguishing between beneficial and pathogenic bacteria in a manner that modulates bacterial growth.
Gustation; Neuronal dynamics of taste sensation and taste-related decisions.
Structural and mechanistic studies on proteins and protein assemblies in innate immunity, inflammation, host-pathogen interactions, membrane trafficking, and autophagy.
Using gametogenesis as a model to study cellular rejuvenation; mechanisms of chromosome tethering at the nuclear envelope
Kaposi's sarcoma-associated herpesvirus (KSHV); viral evasion of the host innate immune responses; viral modulation of the host kinase signaling pathways; role and assembly of KSHV tegument proteins.