Students may choose to work with any Department of Biological Science faculty. With permission from the Associate Chair for Graduate Studies, students may also forge collaborative thesis projects between biology faculty and any other faculty at Florida State University.
My laboratory takes a novel and innovative approach to studying colorectal cancer by leveraging sophisticated genetic tools and practical advantages of Drosophila. We build, study and drug-screen Drosophila cancer models that reflect the complexity and diversity of sequenced human tumors.
Meiosis in higher plants; telomere dynamics; molecular cytology; maize chromatin, nuclease sensitivity profiling, G4-DNA, and genome research in maize and hop.
X chromosome inactivation; chromatin organization; epigenetic gene regulation.
Biomechanics of cardiac and skeletal muscle.
Cell fate specification and reprogramming in plants; evolutionary and developmental biology; plant-environment interaction; genomics and epigenomics; proteomics; molecular genetics.
The biology of chromatin involved in the innate immune response.
Structure and Function of Ion Channel Proteins; Signal Transduction and Neuromodulation by Phosphorylation; Impact of Obesity and Diabetes mellitus on Olfactory and Sensory Processes
Using zebrafish as an model system, we investigate genetic & cellular mechanisms regulating photoreceptor development, patterning, retinal degeneration and regeneration.
Muscle contraction; structure-function of proteins; cellular physiology.
Epigenetic regulation of neuropsychiatric disorders
Our laboratory uses biophysical techniques including quantitative live-cell imaging, single virus tracking, and correlative cryo-Electron Tomography approaches to gain mechanistic and structural insights into virus-host interactions. Specifically, we are interested in understanding the cell-biology underlying the disassembly and transport of single virus particles such as HIV-1 to their replication centers inside the nucleus
Dynamic changes in chromatin and chromosome architecture regulates patterns of cellular gene expression during differentiation and development, or in response to environmental signals. Our research looks at various levels of chromatin, chromosome and nuclear structure, from individual nucleosome modifications to the dynamic 3D structure of chromosomes and their inter-relationships in the nucleus and how they affect genome functions.
Replication, Transcription and Genome Architecture in Stem Cells
I study the symbiotic interaction of nitrogen-fixing rhizobial bacteria with legume host plants: 1)How bacteria manipulate their environment during host plant invasion such that the plant not only permits entry, but provides an invasion pathway for them; 2)Why the interactions of specific strains of Sinorhizobium with particular Medicago truncatula plant ecotypes are more productive than others; 3)How plants direct resources to productive symbionts at the expense of unproductive ones (cheaters).
Biological membranes; cell-substrate interactions; bionanotechnology.
Signaling and circadian modulation regulating associative memory.
Epigenetic gene regulation in maize.
Molecular and statistical properties of adaptive evolution.
Sensory processing, function and organization of neural circuits, imaging brain activity.
The Stroupe laboratory uses cryogenic electron microscopy and X-ray crystallography to discover fundamental mechanisms in ribosome biogenesis and sulfur metabolism.
Virus-host cell interactions; Cell biology of HCV and flavirus replication; Cellular co-factors for HCV and flavivirus (dengue virus, Zika virus)infection.
Macromolecular structure determination by 3-D electron microscopy; muscle, cytoskeleton and cell adhesion structure; virus structure.
Gustation; Neuronal dynamics of taste sensation and taste-related decisions.
Biochemist and structural biologist dedicated to delineate individual proteins functions and their interactions in innate immunity, inflammation, pathogen-host interaction, and autophagy.
Molecular and cell biology of the cell nucleus
Kaposi's sarcoma-associated herpesvirus (KSHV); viral evasion of the host innate immune responses; viral modulation of the host kinase signaling pathways; role and assembly of KSHV tegument proteins.