BIOLOGICAL
SCIENCEFACULTY MEMBER Dr. James M. Fadool
Personal Home Page  Associate Professor; Ph.D., Michigan State University, 1992 Research and Professional Interests: Vertebrate embryology, genetic and biochemical mechanisms regulating development and degenerative diseases of the visual system. Novel transgenic technologies for identification of transcriptionally active regions of the genome using the zebrafish as a model organism. Selected Publications:
Fadool, J.M., Brockerhoff, S.E., Hyatt, G.A. and Dowling, J.E. (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev. Genetics. 20:288-295. Fadool, J.M., Hartl, D.L. and Dowling, J.E. (1998) Transposition of the mariner element from Drosophila mauritiana in zebrafish (Danio rerio). Proc. Natl. Acad. Sci. USA 95:5182-5186. McCune, A.R., Fuller, R.C., Aquilina, A.A., Dawley, R.M., Fadool, J.M., Houle, D., Travis, J., Kondrashov, A.S. (2002) A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish. Science 296:2398-401. Fadool, J.M. (2003) Development of a rod photoreceptor mosaic revealed in transgenic zebrafish. Dev. Biol. 258:277-290. DeCarvalho, A.C., Cappendijk, S. and Fadool, J.M. (2004) Expression of the Pou domain transcription factor, Brn3b in the lateral line and retina of zebrafish. Dev. Dynamics 229:869-876. Vihtelic T.S., Fadool, J.M., Thornton, K., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Mol Vision. 11:1083-1100. Morris, A.C., Schroeter, E.H., Bilotta, J, Wong, R.O., and Fadool, J.M. (2005) Cone survival despite rod degeneration in transgenic zebrafish. Invest. Ophthalmol. Visual Sci. 46:4762-4771. Stearns, G., Evangelista, M., Fadool, J.M., and Brockerhoff, S.E. (2007) A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish.
J Neurosci. 27:13866-74. Morris, A.C., Scholz, T.L., Brockerhoff, S.E., and Fadool, J.M. (2008) Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol. 68:605-19. Alvarez-Delfin, K., Morris, A.C., Snelson, C.D., Gamse, J.T., Gupta, T., Marlow, F.L., Mullins, M.C., Burgess, H.A., Granato, M., Fadool, J.M. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci U S A. 106:2023-2028. Graduate Students: Alvarez-Delfin, Karen |
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Dr. James M. Fadool - FSU Biological Science Faculty Member