Vertebrate embryology, genetic and biochemical mechanisms regulating development and degenerative diseases of the visual system. Novel transgenic technologies for identification of transcriptionally active regions of the genome using the zebrafish as a model organism.

Selected Publications:

Fadool, J.M., Brockerhoff, S.E., Hyatt, G.A. and Dowling, J.E. (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev. Genetics. 20:288-295.
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Fadool, J.M., Hartl, D.L. and Dowling, J.E. (1998) Transposition of the mariner element from Drosophila mauritiana in zebrafish (Danio rerio). Proc. Natl. Acad. Sci. USA 95:5182-5186.
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McCune, A.R., Fuller, R.C., Aquilina, A.A., Dawley, R.M., Fadool, J.M., Houle, D., Travis, J., Kondrashov, A.S. (2002) A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish. Science 296:2398-401.
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Gregg, R.G., Willer, G.B., Fadool, J.M., Dowling, J.E., Link, B.A. (2003) Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation. Proc Natl Acad Sci U S A. 100:6535-40.
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Fadool, J.M. (2003) Development of a rod photoreceptor mosaic revealed in transgenic zebrafish. Dev. Biol. 258:277-290.
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Fuller, R.C., Carleton, K.L., Fadool, J.M., Spady, T.C., & Travis, J. (2004) Population variation in opsin expression in the bluefin killifish, Lucania goodei: a real-time PCR study. J Comp Physiol A 190:147-154.
[View abstract]

DeCarvalho, A.C., Cappendijk, S. and Fadool, J.M. (2004) Expression of the Pou domain transcription factor, Brn3b in the lateral line and retina of zebrafish. Dev. Dynamics 229:869-876.
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Fuller, R.C., Carleton, K.L., Fadool, J.M., Spady, T.C., Travis, J. (2005) Genetic and environmental variation in the visual properties of bluefin killifish, Lucania goodei. J. Evol. Biol. 18:516-23.
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Morris A.C. , and Fadool, J.M. (2005) Studying rod photoreceptor development in zebrafish. Physiology Behav. 86:306-13.
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Vihtelic T.S., Fadool, J.M., Thornton, K., Hyde, D.R., and Wistow, G. (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. Mol Vision. 11:1083-1100.
[View abstract]

Morris, A.C., Schroeter, E.H., Bilotta, J, Wong, R.O., and Fadool, J.M. (2005) Cone survival despite rod degeneration in transgenic zebrafish. Invest. Ophthalmol. Visual Sci. 46:4762-4771.
[View abstract]

Morris, Ann C.

Graduate Students:

Alvarez-Delfin, Karen
Millet, Alisa
Moldstad, Amanda Joelle
Pflueger, Melissa
Saade, Carole

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