Vertebrate embryology, genetic and biochemical mechanisms regulating development and degenerative diseases of the visual system. Novel transgenic technologies for identification of transcriptionally active regions of the genome using the zebrafish as a model organism.

Morris, A. C., M. A. Forbes-Osborne, L. S. Pillai, and J. M. Fadool (2011) Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration.. Invest Ophthalmol Vis Sci. 52: 2255-2266.
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Alvarez-Delfin, K., A. C. Morris, C. D. Snelson, J. T. Gamse, T. Gupta, F. L. Marlow, M. C. Mullins, H. A. Burgess, M. Granato, and J. M. Fadool (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proc Natl Acad Sci USA. 106: 2023-2028.
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Morris, A. C., T. L. Scholz, S. E. Brockerhoff, and J. M. Fadool (2008) Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev Neurobiol. 68: 605-619.
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Stearns, G., M. Evangelista, J. M. Fadool, and S. E. Brockerhoff (2007) A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish. J Neurosci. 27: 13866-74.
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Vihtelic, T. S., F. J. M, T. K. A, and H. D. R (2005) Expressed sequence tag analysis of zebrafish eye tissues for NEIBank. . Mol Vision 13: 1083-1100.
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Morris, A. C., S. E. H, W. R. O, and F. J. M (2005) Cone survival despite rod degeneration in XOPS-mCFP transgenic zebrafish.. Invest Ophthalmol Vis Sci. 46: 4762-71.
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DeCarvalho, A. C., S. Cappendijk, and J. M. Fadool (2004) Expression of the Pou domain transcription factor, Brn3b in the lateral line and retina of zebrafish. Dev. Dynamics 229: 869-876.
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Fadool, J. M. (2003) Development of a rod photoreceptor mosaic revealed in transgenic zebrafish. Dev. Biol. 258: 277-290.
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McCune, A. R., R. C. Fuller, A. A. Aquilina, R. M. Dawley, J. M. Fadool, D. Houle, J. Travis, and A. S. Kondrashov (2002) A low genomic number of recessive lethals in natural populations of bluefin killifish and zebrafish. Science 296: 2398-401.
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Fadool, J. M., D. L. Hartl, and J. E. Dowling (1998) Transposition of the mariner element from Drosophila mauritiana in zebrafish (Danio rerio). Proc. Natl. Acad. Sci. USA 95: 5182-5186.
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Fadool, J. M., S. E. Brockerhoff, G. A. Hyatt, and J. E. Dowling (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Dev. Genetics 20: 288-295.
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Graduate Students:

Benoit, Chelsea
Rajkumari, Gayatri
Saade, Carole
Sotolongo-Lopez, Mailin

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