Biological Science Faculty Member
Dr. Hank W. Bass
- Office: 3074 King Life Sciences
- Office: (850) 644-9711
- Lab: King Life Sciences
- Lab: (850) 644-8058
- Fax: (850) 645-8447
- Mail code: 4295
Ph.D., North Carolina State University, 1992.
Graduate Faculty Status
Working model of chromatin signatures from nuclease sensitivity profiling using
DNS (Differential Nuclease Sensitivity) mapping, from Vera et al., 2014.
Research and Professional Interests:
Our work makes use of maize (corn, Zea mays L.) as a model genetic system to investigate fundamental questions about the inheritance and function of genetic material at the cellular and molecular level. We employ genetics, microscopy, molecular biology, and genomics to examine chromosome form and function. Our work has broad implications for not only plant biology, but also for genetics more broadly.
Current research is advancing in several related areas, including:
Meiotic Chromosome Behavior
- Meiotic telomeres, nuclear envelope SUN-domain, LINC complex proteins in chromosome segregation
- Meiotic chromosome behavior in hop
Epigenomics and chromatin structure using genome-wide nuclease sensitivity profiling
G-quadruplex (G4) DNA in maize as potential regulatory motifs for plant energy stress
DNA replication in developing maize root tip nuclei, 3D cytogenetics
(2017) Savadel SD and Bass HW. "Take a Look at Plant DNA Replication: Recent Insights and New Questions." Plant Signaling & Behavior, 12:4, e1311437.
(2016) Rodgers-Melnick E, Vera DL, Bass HW, and Buckler ES. "Open Chromatin Reveals the Functional Maize Genome." Proc Nat Acad Sci, USA 113(22):E3177-E3184.
(2015) Kopylov M, Bass HW, and Stroupe ME. "The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA" Biochemistry 54(9):1743-1757.
(2014) Vera DL, Madzima TF, Labonne JD, Alam MP, Hoffman GG, Girimurugan SB, Zhang J, McGinnis KM, Dennis JH, and Bass HW. "Differential nuclease sensitivity profiling of chromatin reveals biochemical footprints coupled to gene expression and functional DNA elements in maize." Plant Cell 26(10):3883-3893.
(2014) Andorf CM, Kopylov MS, Dobbs D, Koch KE, Stroupe ME, Lawrence CJ, and Bass HW. "G-quadruplex motifs in maize (Zea mays L.) occupy specific sites in thousands of genes coupled to energy status, hypoxia, low sugar, and nutrient deprivation" J Genetics Genomics 41(12):627-647.
(2014) Murphy SP, Gumber HK, Mao YY, and Bass HW. "A dynamic meiotic SUN belt includes the zygotene-stage telomere bouquet and is disrupted in chromosome segregation mutants of maize (Zea mays L.)." Frontiers in Plant Science 5:314.
(2014) Bass HW, Wear EE, Lee T-J, Hoffman GG, Gumber HK, Allen GC, Thompson WF, Hanley-Bowdoin L. "A maize root tip system to study DNA replication programmes in somatic and endocycling nuclei during plant development" J Exp Botany 65:2747-2756.
(2013) Fincher JA, Vera DL, Hughes DD, McGinnis KM, Dennis JH, and Bass HW. "Genome-wide prediction of nucleosome occupancy in maize (Zea mays L.) highlights chromatin structural features at multiple scales." Plant Physiol 162(2):1127-1141.
(2013) Graumann K, Bass HW, and Parry G. "SUNrises on the International Plant Nucleus Consortium: SEB Salzburg 2012" Nucleus 4(1):3-7 dx.doi.org/10.4161/nucl.23385.
(2012) Howe ES, Clemente TE, and Bass HW. "Maize histone H2B-mCherry, a new fluorescent chromatin marker for somatic and meiotic chromosome re search." DNA and Cell Biology. 31(6):925-938. (DOI: 10.1089/dna.2011.1514).
(2012) Figueroa DM and Bass HW. "Development of pachytene FISH maps for six maize chromosomes and their integration with other maize maps for insights into genome structure variation." Chromosome Research 20(4):363-380. (DOI: 10.1007/s10577-012-9281-4)
(2012) Murphy SP and Bass HW. "The maize (Zea mays L.) desynaptic (dy) mutation defines a pathway for meiotic chromosome segregation linking nuclear morphology, telomere distribution, and synapsis." J Cell Science 125(15):3681-3690. (doi: 10.1242/jcs.108290)
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