Biological Science Faculty Member
Dr. Qian Yin
- Office: 506 Kasha Laboratory
- Office: 850-644-1747
- Lab: Kasha Laboratory
- Lab: 850-644-2286
- E-mail: email@example.com
Ph.D., Weill Cornell Medical College, 2008; Postdoc, Weill Cornell Medical College, 2012; Boston Children's Hospital, 2015
Graduate Faculty Status
Research and Professional Interests:
My lab is interested in how individual proteins, or protein assemblies, mediate biological processes in the linked areas of innate immunity, inflammation and host-pathogen interactions. Longer-term perspectives extend to the interplay between inflammation, infection, autophagy, and cytoskeleton rearrangement. We study the mechanisms of pathogen-associated molecular patterns (PAMPs) recognition, viral restriction, evasion or suppression of host immunity and their intricate network using a combination of biochemical, structural (including X-ray crystallography and cryo-EM), cellular and pharmacological approaches.
Mechanistic and structural studies of IFN-inducible GTPases
GTPases have been meticulously documented for their roles to regulate multiple cellular processes spanning from cell mobility, membrane fusion and fission, to cytokinesis and vesicle transport. IFN-inducible GTPases, consisting of more than forty members in human and mice, are conserved from vertebrates to human. They are among the most highly expressed ISGs, sometimes accounting for twenty percent of all proteins induced by IFN-γ. Yet the functions of IFN-inducible GTPases remain largely unknown.
IFN-inducible GTPases can be classified into three major subfamilies: guanylate-binding proteins (GBPs), immunity-related GTPases (IRGs), and myxovirus resistance (Mx) proteins. IRGs can be further divided into GKS and GMS IRGs based on sequence features. They are all part of cell-autonomous resistance against microbial infections by patrolling the intracellular space, targeting pathogen-containing vacuoles (PVs) and viruses, promoting inflammasome formation, and coordinating assembly of oxidative and autophagic complexes for wide-spectrum pathogens elimination.
I propose to study the working mechanisms and structure-function relationships of GBPs and IRGs.
1. Elucidating GBP self-organization by biochemical, structural and microscopic methods
2. Understanding the specificity of GBPs and IRGs towards foreign entities
3. Revealing the pathogen counterattack strategies
Highly motivated individuals are welcome to contact Dr. Yin for positions at all levels: undergraduate student researchers, graduate students, postdoctoral fellows, and technicians.
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