Dr. Kimberly A. Hughes
Laboratory Home Page
Ph.D., University of Chicago, 1993
Graduate Faculty Status
Research and Professional Interests:
Organisms are enormously genetically diverse. Even traits subject to strong natural selection, such as fertility, longevity, and reproductive behavior can vary greatly among individuals within a single population, and much of this variation can be heritable. We strive to understand why so much genetic variation persists for traits under strong selection and also to understand the consequences of this diversity for individuals, species, and communities. Members of the lab are studying the genetic, genomic, and evolutionary determinants of life span; the ecological genetics of sexual selection and mate choice; and genetic and nongenetic modifiers of aggressive behavior. We use different experimental organisms, including fruit flies and several species of poeciliid fish, and a diversity of techniques, including quantitative genetics, evolutionary and behavioral genomics and field experiments.Selected Publications:
Hughes, K. A., Houde, A. E., Price, A. C., & Rodd, F. H. 2013. Rare male mating advantage in wild guppy populations. Nature 503:108-110.
Fraser, B. A., Hughes, K. A., Tosh, D. A., & Rodd, F. H. 2013. The role of learning by a predator, Rivulus hartii, in the rare-morph survival advantage in guppies. Journal of Evolutionary Biology, Published online ahead of print Oct 7, 20103, 9 pages.
Remolina, S.C. Chang, P.L., Leips, J., Nuzhdin, S.V., and K.A. Hughes. 2012. Genomic basis of aging and life-history evolution in Drosophila melanogaster. Evolution 66:3390-3403.
Felix, T.M., Hughes, K.A. Stone, E.A., Drnevich, J.M., and J. Leips. 2012. Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Genetics 191:989-1002.
Fraser, B.A., Weadick, C.J., Janowitz, I., Rodd, F.H, and K.A. Hughes 2011. Sequencing and characterization of the guppy (Poecilia reticulata) transcriptome. BMC Genomics 12:202 (14 pages).
Hughes, K.A. 2010. Mutation and the evolution of ageing: from biometrics to systems genetics. Philosophical Transactions of the Royal Society, London: 365:1273-1279.
Bushey, D., K. A. Hughes, G. Tononi, and C. Cirelli. 2010. Sleep, aging, and lifespan in Drosophila. BMC Neuroscience 11:56 (8 pages).
Olendorf, R., F. H. Rodd, D. Punzalan, A. E. Houde, C. Hurt, D. N. Reznick, and K. A. Hughes. 2006. Frequency-dependent survival in natural guppy populations. Nature 441:633-636.
Drnevich, J., M. Murray, E. Ruedi, S. Rodriguez-Zas, and K. A. Hughes. 2004. Quantitative evolutionary genomics: differential gene expression and male reproductive success in Drosophila melanogaster. Proceedings of the Royal Society of London, B 271:2267-2273.