Dr. Kimberly A. Hughes
Laboratory Home Page
Ph.D., University of Chicago, 1993
Graduate Faculty Status
Organisms are enormously genetically diverse. Even traits subject to strong natural selection, such as fertility, longevity, and reproductive behavior can vary greatly among individuals within a single population, and much of this variation can be heritable. We strive to understand why so much genetic variation persists for traits under strong selection and also to understand the consequences of this diversity for individuals, species, and communities. Members of the lab are studying the genetic, genomic, and evolutionary determinants of life span; the ecological genetics of sexual selection and mate choice; and genetic and nongenetic modifiers of aggressive behavior. We use different experimental organisms, including fruit flies and several species of poeciliid fish, and a diversity of techniques, including quantitative genetics, evolutionary and behavioral genomics and field experiments.Selected Publications:
Ghalambor, CK, Hoke, KL, Ruell, E, Fisher, EK, Reznick, DN, & Hughes, KA (2015) Non-adaptive plasticity potentiates rapid adaptive evolution of gene expression in nature. Nature (In press).
Hughes KA, Houde AE, Price AC, & Rodd FH (2013) Mating advantage for rare males in wild guppy populations. Nature 503:108-110.
Remolina SC, Chang PL, Leips J, Nuzhdin SV, & Hughes KA (2012) Genomic basis of aging and life-history evolution in Drosophila melanogaster. Evolution 66:3390-3403.
Felix TM, Hughes KA, Stone EA, Drnevich JM, & Leips J (2012) Age-specific variation in immune response in Drosophila melanogaster has a genetic basis. Genetics 191:989-1002.
Hughes KA (2010) Mutation and the evolution of ageing: from biometrics to system genetics. Philosophical Transactions of the Royal Society B 365:1273-1279.