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Dr. David M. Gilbert —FSU Biological Science Faculty Member -->

Dr. David M. Gilbert

Office: 3066 King Life Sciences
Office: (850) 645-7583
Lab: King Life Sciences
Lab: (850) 645-7584
Fax: (850) 644-9399
Mail code: 4295

Laboratory Home Page

J. Herbert Taylor Distinguished Professor of Molecular Biology
Ph.D., Stanford University, 1989
Graduate Faculty Status

Dr. David Gilbert is currently recruiting new graduate students for Fall 2016.

Research and Professional Interests:

Our overall goal is to understand how mammalian chromosomes are organized within the nucleus to carry out their various functions. DNA replication provides an excellent forum with which to study chromosome structure and function. Structural and functional units of chromosomes replicate coordinately, often through the synchronous firing of clusters of replication origins that encompass domains of approximately 1Mb. Each of these replication domains is programmed to replicate at a specific time during S-phase. In general, transcriptionally active (euchromatin) domains replicate early in S-phase and transcriptionally silent (heterochromatin) domains replicate late. Programmed changes in replication timing accompany key stages of metazoan development and are often coupled to changes in gene expression. These findings suggest that structural, functional, and replication domains share topographical boundaries and represent basic units of chromosome organization. We would like to understand what regulates where and when replication initiates and, ultimately, how developmental cues communicate with the cell-cycle machinery to elicit changes in the program for replication and how that program is disrupted in cancer.

Selected Publications:

Click here for the most up-to-date publications on PubMed

Postdoctoral Associates:

Rivera Mulia, Juan Carlos

Graduate Students:

Bartlett, Daniel
Dileep, Vishnu
Klein, Kyle
Sima, Jiao
Wilson, Korey

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