Emily Darrow (Ph.D., 2018)
CMB graduate student in the Chadwick lab.
The roles of many tandem-repeat DNA sequences in the human genome are unknown. DXZ4 is a large X-linked macrosatellite implicated in the structure of the inactive X chromosome (Xi). Using cutting-edge genome engineering tools, Emily excised DXZ4 from the Xi, causing large-scale local chromatin changes to the Xi. In collaboration with Dr. Erez Lieberman-Aiden's group, we showed compromised Xi 3D conformation. This work involved three members of the CMB Graduate Program: Emily Darrow, Zhuo Sun and Andrew Seberg. Emily defended her Ph.D. in 2017 and is starting a postdoc in 2018.
Darrow, E. M., M. H. Huntley, O. Dudchenko, E. K. Stamenova, N. C. Durand, Z. Sun, S. C. Huang, A. L. Sanborn, I. Machol, M. Shamim, A. P. Seberg, E. S. Lander, B. P. Chadwick and E. L. Aiden (2016). "Deletion of DXZ4 on the human inactive X chromosome alters higher-order genome architecture." Proc Natl Acad Sci U S A 113(31): E4504-4512.
The Cell and Molecular Biology graduate program within the Department of Biological Science offers an exceptional variety of opportunities for students seeking to work in cellular and molecular biology. We use a wide range of organisms and technologies to investigate basic biological processes. Fundamental research in the areas of cell structure, motility, and development are complemented by other areas of research such as those focusing on the genetic control of cellular behavior, the regulation of gene expression, the dynamic maintenance of genetic information, and the physiology of organisms.
Cell and Molecular Biology faculty, postdocs, and students work together to discover and publish major findings in the broad-reaching and high-impact fields that comprise modern cellular and molecular biology.
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