Brooke R. Druliner is a doctoral candidate in Dr. Jonathan Dennis´ lab. The overall goal of her dissertation work is to elucidate the role of chromatin structure in the progression of cancer by studying primary patient tumors of multiple cancer types. We hope this project will reveal new insights into the current knowledge of chromatin structure, and examine the chromatin structural regulation of cancer progression. Brooke recently published a major manuscript in Cell Cycle, showing for the first time that the progression of lung cancer is linked to specific alterations in chromatin structure at multiples levels of resolution.
ARTICLE: Druliner B, Fincher J, Sexton B, Vera D, Roche M, Lyle S, Dennis J. (2013) Chromatin patterns associated with lung adenocarcinoma progression. Cell Cycle 12:1536 - 1543. http://dx.doi.org/10.4161/cc.24664.