General Genetics


Department of Biological Science

College of Arts and Sciences

The Florida State University


Lecture: M W F 11:15 am Spring 2005

Room: 228 Conradi Bldg.


Instructor: James M. Fadool Phone:644-3550

Office: 235 Biomedical Research Facility

Office Hours: M R 12:30-1:30; Or by appointment.

Help Session: M, 515-615, 208 BIO


TA: Rizkallah, Raed
Phone: 850-644-4233




Required Text: Essentials of Genetics, 5th ed. W.S.Klug and M.R. Cummings;

Prentice Hall, 2005.

Essentials of Genetics, Student Handbook & Solutions Manual,

H. Nickla, Prentice Hall, 2005.



This is an exciting time to be a geneticist. The human genome project, computer resources and computational methods and the ever-growing methodologies for manipulating genes have propelled a field fundamental to all areas of biology. The objective of this course is to provide undergraduate students with an understanding of the fundamental concepts of genetics and molecular biology. Apart from being a required course for majors in Biological Science and strongly recommended for others interested in careers in medicine or allied health professions, genetics shapes our understanding of human health and disease, evolution, agriculture, conservation biology and yes even political affairs. The transmission of genetic material from one generation to the next is what makes biology truly unique amongst the natural sciences. The classical experimental investigations illustrate the development of the scientific method and the evolution of genetics as a field of study. The principles of human genetics, methods in molecular biology and the lessons from cancer biology demonstrate the applications of genetics to our understanding of health and disease in society.


The lecture material is divided into 2 general areas, Transmission Genetics and Molecular Genetics. The reading assignments are intended to prepare the students for the lectures. When reading, you should focus on the goals as outlined in the text and familiarize yourself with the terminology. More so than many areas of biology, analytical skills and problem solving are fundamental to an understanding of transmission genetics. The recommended problems in the back of each chapter highlight the important points of study and the applications of the lecture material. The solutions to several questions will be reviewed in the help session held each week. Although attendance is not compulsory, it is strongly encouraged.


Grade Policy: There will be three one-hour exams, each worth 20% of the final grade, and a final exam, worth 40% of the final grade. The hour exams will emphasize material covered in that quarter of the course, but students are responsible for all course material presented to that date. The final exam will be cumulative with a section devoted to the latest class material and others that specifically address topics from the first 3 sections of the course.


Quizzes covering the reading material, lecture material, or recommended problems will be given at the beginning of class on a regular but unannounced basis. The most obvious goal is to encourage each student to come to class prepared for lecture and having reviewed previous material. Genetics covers a broad range of principles from inheritance and probability to molecular biology and its applications. Preparation is essential. A second goal is to provide students with samples of the types of questions and depth of understanding to be expected on the Exams. There are no Old Exams. The average on the quizzes count as bonus point and will be factored into the hourly exam score for that section of the course. There will be no make-up quizzes as these will be graded immediately following administration. There will be no extra credit, so take advantage of the opportunity offered by the quizzes to improve your grade. There is no rounding-up of averages.



Grade Scale:

A 93-100 C+ 77-79

A- 90-92 C 70-78

B+ 87-89 C- 66-69

B 83-86 D 60-65

B- 80-82 F Below 60


Students with disabilities needing academic accommodation should; (1) register with and provide documentation to the Student Disability Resource Center; (2) bring a letter to the instructor indicating the need for accommodation and what type. This should be done during the first week of class.


Attendance at lectures should not be viewed as unnecessary. There is no substitute for the interaction between the instructor and students. Questions during lecture are actively encouraged. Furthermore, supplemental information, not present in the text, may be provided. Likewise, it is expected that students will study the assigned material in the text as all requisite information cannot be presented in lecture.


Attendance at Lecture Exams is required. Absences will only be condoned if an Acceptable and Verifiable excuse is provided as outlined in the Student Handbook. Students are expected to uphold the Academic Honor Code. Failure to take an examination at the designated time will result in a ZERO (0) score. The Academic Honor System of The Florida State University is based on the premise that each student has the responsibility (1) to uphold the highest standards of academic integrity in the student's own work, (2) to refuse to tolerate violations of academic integrity in the university community, and (3) to foster a high sense of integrity and social responsibility on the part of the university community.

Proposed Course Schedule


Lecture Date Topic Chapter



1 Jan 5 Introduction; History of Genetics 1: 2,4,6

2 7 Cell Cycle Review 2: 1-5,8,12,13,15,17



3 10 Mendelian Principles 3: 1,2,5,6,7,8,11,13,14,16,24

4 12 Mendelian Principles 3

5 14 Probability & Human Pedigrees 3



7 19 Modifications of Mendelian Ratios 4

8 21 X-Linkage 4



9 24 Additional Gene Interactions 4

10 26 Sex Differentiation 5

11 28 Imprinting & Dosage Compensation 4 & 5


12 31 Quantitative Genetics 6

13 Feb 2 Complete & Review Section 1

14 4 **** LECTURE EXAM 1 ******



15 7 Cytogenetics 7

16 9 Chromosome Variation 1 7

17 11 Chromosome Variation 2 7



18 14 Linkage in Eukaryotes 8

19 16 Linkage in Eukaryotes 8

20 18 Population Genetics 22



21 21 Population Genetics 22

22 23 DNA as Heredity Material 10

23 25 Chemical Structure of Nucleic Acids 10


24 28 Complete & Review Section 2

25 Mar 2 **** LECTURE EXAM 2 ******

26 4 DNA Replication 11






27 14 DNA Replication 11

28 16 DNA Structure and Organization 12

29 18 Transcription 13



30 21 Introns-Processing 13

31 23 Translation 14

32 25 Translation and Proteins 14


33 28 Hemoglobin & Sickle Cell Anemia pp 307-309

34 30 Regulation of Eukaryote Transcription 16

35 Apr 1 Review 12



36 4 **** LECTURE EXAM 3 ******

37                         6 Library Resources TBA

38                         8 Mutations 15



39 11 Developmental Genetics 20

40 13 Developmental Genetics 2 TBA

41 15 Cancer Genetics 21



42 18 Molecular Techniques 17

43 20 Student Selected Topic

44 22 Review



April 28 *******FINAL EXAM*******