Gaffney Publications

images/Betty J. Gaffney.jpg (3557 bytes)

Oldies but Goodies (representative earlier publications)

Some early publications were published under the name Betty Gaffney McFarland.

Lipoxygenase and EPR of Metalloproteins

Bloom, L. M., B. J. Gaffney, and S. J. Benkovic. 1986. Characterization of phenylalanine hydroxylase. Biochemistry 25:4204-4210. PMID: 3019383. Full text, PDF
Yang, A.-S, and B. J. Gaffney. 1987. Determination of relative spin concentration in some high-spin ferric proteins using E/D-distribution in electron paramagnetic resonance simulations. Biophysical Journal 51:55-67. PMID: 3026504. Full text, PDF
Gaffney, B. J., D. V. Mavrophilipos, and K. S. Doctor. 1993. Access of ligands to the ferric center in lipoxygenase-1. Biophysical Journal 64:773-783. PMID: 8386016. Full text, PDF
Gaffney, B. J., and H. J. Silverstone. 1993. Simulation of the EMR spectra of high spin iron in proteins. Pages 1-57 of L. J. Berliner and J. Reuben, Eds. Biological Magnetic Resonance, Vol. 13: EMR of Paramagnetic Molecules. Plenum, New York.
Doctor, K. S., and B. J. Gaffney. 1996. High frequency EPR predictions for the non-heme iron protein lipoxygenase. Applied Magnetic Resonance 11:425-435.
Boyington, J. C., B. J. Gaffney, and L. M. Amzel. 1993. The three-dimensional structure of an arachidonic acid 15-lipoxygenase. Science 260:1482-1486. PMID: 8502991. Full text, PDF
Crowder, M. W., J. D. Stewart, V. A. Roberts, C. J. Bender, E. Tevelrakh, S. D. Taylor, P. C. D. Hawkins, S. Franklin, J. Peisach, E. D. Getzoff, B. J. Gaffney, and S. J. Benkovic. 1995. Spectroscopic studies on the designed metal-binding sites of the 43C9 single chain antibody. Journal of the American Chemical Society 117:5627-5634. Full text, PDF
Prigge, S. T., J. C. Boyington, B. J. Gaffney, and L. M. Amzel. 1996. Structure conservation in lipoxygenases: structural analysis of soybean lipoxygnase-1 and modeling of human lipoxygnases. Proteins: Structure, Function, and Genetics 24:275-291. PMID: 8778775
Gaffney, B. J., G. R. Eaton, and S. S. Eaton. 1998. Electron spin relaxation rates for high-spin Fe(III) in iron transferrin carbonate and iron transferrin oxalate. Journal of Physical Chemistry B 102:5536-5541. PMID: 16429607. Full text, PDF

Structure and Dynamics of Lipid Membranes

Gaffney McFarland, B., and H. M. McConnell. 1971. Bent fatty acid chains in lecithin bilayers. Proceedings of the National Academy of Sciences of the USA 68:1274-1278. PMID: 4331085. Full text, PDF
Gaffney, B. J., and H. M. McConnell. 1974. Effect of a magnetic field on phospholipid membranes. Chemical Physics Letters 24:310-313.
Gaffney, B. J., and H. M. McConnell. 1974. The paramagnetic resonance spectra of spin labels in phospholipid membranes. Journal of Magnetic Resonance 16:1-28. Full text, PDF
Gaffney, B. J. 1975. Fatty acid chain flexibility in the membranes of normal and transformed fibroblasts. Proceedings of the National Academy of Sciences of the USA 72:664-668. PMID: 164663.
Sefton, B. M., and B. J. Gaffney. 1974. Effect of the viral proteins on fluidity of the membrane lipids in Sindbis virus. Journal of Molecular Biology 90:343-358. PMID: 4375723. Full text, PDF
Sefton, B. M., and B. J. Gaffney. 1979. Complete exchange of viral cholesterol. Biochemistry 18:436-442. PMID: 217416. Full text, PDF
Wey, R. C., L. A. Cone, and B. J. Gaffney. 1979. Effects of light and C-GMP on membrane fluidity of frog rod outer segments. Photochemistry and Photobiology 29:707-713. PMID: 221948.
Chen, S. C., J. M. Sturtevant, and B. J. Gaffney. 1980. Scanning calorimetric evidence for a third phase transition in phosphatidylcholine bilayers. Proceedings of the National Academy of Sciences of the USA 77:5060-5063. PMID: 6933546.
Gaffney, B. J. 1996. Lipoxygenases: structural principles. Annual Review of Biophysics and Biomolecular Structure 25: 431-459. PMID: 8800477. Full text, PDF
Gaffney, B. J., C. Su, and E. H. Oliw. 2001. Assignment of EPR transitions in a manganese-containing lipoxygenase and prediction of local structure. Applied Magnetic Resonance 21: 413-424. PMID: 16518455. Full text, PDF

Development and Application of Spin Label Technology

McConnell, H. M., and B. Gaffney McFarland. 1970. Physics and chemistry and spin labels. Quarterly Reviews of Biophysics 3:91-136. PMID: 4908377 Full text, PDF
Gaffney, B. J. 1976. The chemistry of spin labels. Pages 182-238 in L. J. Berliner, ed. Spin Labeling: Theory and Applications. Academic Press, New York.
Tse-Tang, M. W., B. J. Gaffney, and R. E. Kelly. 1981. Synthesis of bifunctional spin label molecules and their orientations in membranes. Heterocycles 15:965-974.
Gaffney, B. J., G. L. Willingham, and R. S. Schepp. 1983. Synthesis and membrane interactions of spin label bifunctional reagents. Biochemistry 22:881-892. PMID: 6301528.
Willingham, G. L., and B. J. Gaffney. 1983. Reactions of spin label crosslinking reagents with red blood cell proteins. Biochemistry 22:892-898. PMID: 6301529. Full text, PDF
Gaffney, B. J. 1985. Chemical and biochemical crosslinking of membrane components. Biochimica et Biophysica Acta Reviews on Biomembranes 822:289-317. PMID: 2865974. Full text, PDF
Grill, H., N. Weigel, B. J. Gaffney, and S. Roseman. 1982. Sugar transport by the bacterial phosphotransferase system: XVII. Radioactive and electron paramagnetic resonance labeling of the Salmonella typhimurium phosphocarrier protein HPr at the amino-terminal methionine. Journal of Biological Chemistry 257:14510-14517. PMID: 6292226.

Other Selected Older Publications

Gaffney McFarland, B., Y. Inoue, and K. Nakanishi. 1969. The reaction of Koshland's protein reagent with tryptophan. Tetrahedron Letters 1969:857-860. PMID: 5777661. Full text, PDF
McConnell, H. M., K. L. Wright, and B. Gaffney McFarland. 1972. The fraction of the lipid in a biological membrane that is in a fluid state: a spin-label assay. Biochemical and Biophysical Research Communications 47:273-281. PMID: 4337427. Full text, PDF
Gaffney McFarland, B. 1972. The molecular basis of fluidity in membranes. Chemistry and Physics of Lipids 8:303-313. PMID: 4339480. Full text, PDF
Gaffney, B. J., and R. J. Mich. 1976. A new measurement of surface charge in model and biological lipid membranes. Journal of the American Chemical Society 98:3044-3045. PMID: 942599. Full text, PDF
Chen, S. C., and B. J. Gaffney. 1978. Paramagnetic resonance evidence for phase transitions in bilayers of pure spin labeled lipids. Journal of Magnetic Resonance 29:341-353. Full text, PDF
Gaffney, B. J., C. H. Elbrecht, and J. P. A. Scibilia. 1981. Enhanced sensitivity to slow motions using 15N-nitroxide spin labels. Journal of Magnetic Resonance 44:436-446. Full text, PDF
Scheule, R. K., and B. J. Gaffney. 1981. Reconstitution of membranes with fractions of Triton X-100 which are easily removed. Anal. Biochem. 117:61-66. PMID: 7316198. Full text, PDF
Chen, S.-C., J. M. Sturtevant, K. Conklin, and B.J. Gaffney. 1982. Calorimetric evidence for phase transitions in spin-labeled lipid bilayers. Biochemistry 21:5096-5101. PMID: 7138849. Full text, PDF
Grill, H., N. Weigel, B. J. Gaffney, and S. Roseman. 1982. Sugar transport by the bacterial phosphotransferase system: XVII. Radioactive and electron paramagnetic resonance labeling of the Salmonella typhimurium phosphocarrier protein HPr at the amino-terminal methionine. Journal of Biological Chemistry 257:14510-14517. PMID: 6292226. Full text, PDF
Gaffney, B. J., G. L. Willingham, and R. S. Schepp. 1983. Synthesis and membrane interactions of spin label bifunctional reagents. Biochemistry 22:881-892. PMID: 6301528Full text, PDF
Wallick, D. E., L. M. Bloom, B. J. Gaffney, and S. J. Benkovic. 1984. The reductive activation of phenylalanine hydroxylase and its effect on the redox state of the nonheme iron. Biochemistry 23:1295-1302. PMID: 6324864. Full text, PDF
Boyington, J. C., B. J. Gaffney, and L. M. Amzel. 1990. Crystallization and preliminary x-ray analysis of soybean lipoxygenase-1, a non-heme iron-containing dioxygenase. Journal of Biological Chemistry 265:12771-12773. PMID: 2115880. Full text, PDF
Dubach, J., B. J. Gaffney, K. More, G. R. Eaton, and S. Eaton. 1991. The effect of the synergistic anion on EPR spectra of iron-transferrin anion complexes is consistent with bidentate binding of the anion. Biophysical Journal 59:1091-1100. PMID: 1651123. Full text, PDF
Doctor, K. S., B. J. Gaffney, G. Alvarez, and H. J. Silverstone. 1993. EPR spectroscopy of interdoublet transitions in high-spin iron: applications to transferrin oxalate. J. Phys. Chem. 97:3028-3033. Full text, PDF
Griffith, O. H., B. J. Gaffney, and A. L. Kwiram. 1993. Harden M. McConnell: a celebration of his scientific achievements. J. Phys. Chem. 97:2807-2810. Full text, PDF
Gaffney, B. J. 1996. Lipoxygenases: structural principles and spectroscopy. Ann. Reviews Biophys. Biomol. Struct. 25:431-459. PMID: 8800477. Full text, PDF
Maguire, B. C., and B. J. Gaffney. 1997. Interdoublet transitions in S=5/2 protein systems. Solid State NMR 9:81-83. PMID: 9413907. Full text, PDF
Gaffney, B. J., and H. J. Silverstone. 1998. Simulation methods for looping transitions. J. Magn. Res. 134:57-66. PMID: 9740731. Full text, PDF
Gaffney, B. J., and D. Marsh. 1998. High-frequency, spin label EPR of non-axial ordering and motion in cholesterol-containing membranes. Proc. Natl. Acad. Sci. USA 95:12940-12943. PMID: 9789019. Full text, PDF
Gaffney, B. J., B. C. Maguire, R. T. Weber, and G. G. Maresch. 1999. Disorder at metal sites in proteins: a high frequency EMR study. Appl. Magn. Res. 16:207-222. Full text, PDF
Marsh, D., V. A. Livshits, T. Páli, and B. J. Gaffney. 1999. Recent developments in biological spin-label spectroscopy. Pages 647-650 in Spectroscopy of Biological Molecules: New Directions, J. Greve, G. P. Puppels, and C. Otto, eds. Kluwer, Dordrecht. Full text, PDF
Grant, C. V., W. Cope, J. A. Ball, K. Campbell, G. G. Maresch, B. J. Gaffney, W. Fink, and R. D. Britt. 1999. Electronic structure of the aqueous vanadyl ion probed by 9 and 94 GHz EPR and pulsed ENDOR spectroscopies and density functional theory calculations. J. Phys. Chem. B 103:10627-10631. PMID: 16467924. Full text, PDF
Abraham, B., M. Sono, O. Boutaud, A. Shriner, J. H. Dawson, A. R. Brash, and B. J. Gaffney. 2001. Characterization of the coral allene oxide synthase active site with magnetic circular dichroism and electron paramagnetic resonance spectroscopy: evidence for tyrosinate-ligation to the ferric enzyme heme iron. Biochemistry 40: 2251-2259. PMID: 11329294. Full text, PDF
Gaffney, B. J. 2004. Electron spin resonance of biomolecules. Pages 115-133 in Encyclopedia of Molecular Cell Biology and Molecular Medicine, Vol. 4, R. A. Meyers ed. Wiley-VCH, Weinheim, Germany. Full text, PDF

Publications by BETTY J. GAFFNEY using last name MCFARLAND

B. Gaffney McFarland (1963) "Ring Contraction of Steroids", in Steroids, (ed. C. Djerassi) Holden Day, Inc., San Francisco, Ch. 11, pp. 427-455.
B. Gaffney McFarland (1966) Stanford University thesis: "Reductions by Grignard Reagents with Multiple Asymmetric Centers" (w. H.S. Mosher).
B. Gaffney McFarland, Y. Inoue and K. Nakanishi (1969) "The Reaction of Koshland's Protein Reagent with Tryptophan", Tetrahedron Letters, 10: 857-860.
H. M. McConnell and B. Gaffney McFarland (1970) "Physics and Chemistry and Spin Labels", Quarterly Reviews of Biophysics, 3: 91-136.
B. Gaffney McFarland and H. M. McConnell (1971) "Bent Fatty Acid Chains in Lecithin Bilayers", Proceedings of the National Academy of Sciences, 68: 1274-1278.
H. M. McConnell, K. L. Wright and B. Gaffney McFarland (1972) "The Fraction of the Lipid in a Biological Membrane that is in a Fluid State: A Spin-Label Assay", Biochemical and Biophysical Research Communications, 47: 273-281.
H. M. McConnell and B. Gaffney McFarland (1972) "The Flexibility Gradient in Biological Membranes", Annals of the New York Academy of Sciences, 195: 207-217.
B. Gaffney McFarland (1972) "The Molecular Basis of Fluidity in Membranes", Chemistry and Physics of Lipids, 8: 303-313.

Back to Betty J. Gaffney home page