PDF Links to Primary Literature

Resources for Fall 2021 Class

• Bean B. 2007. The action potential in mammalian central neurons. Nature Reviews 8: 451-465.
• Fundamental Physiological Recordings. Chapters 1-3; Aidley.
• Background on Electricity. Chapters 1, 6-7; Gerrish.
• Watch Rod MacKinnon's Nobel Lecture on Potassium Channels - Click Here
• Gonzalez et al., 2012. K+ Channels: Function-Structural Overview. American Compr Physiol2: 2087-2149.
• Papanikolaou et al., 2020. A critical role for the inward rectifying potassium channel Kir7.1 in oligodendrocytes of the mouse optic nerve. Brain Struct Function 225:925–934.
• Ainscow et al., 2002. Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATPindependent control of ATP-sensitive K+ channels. J. Physiol. 544.2:429–445.
• Petra and Stern, 2017. A type K channel contribute to the prorenin increase in firing frequency in hypothalamic vasopressin neurosecretory neurons. Am. J. Pysiol. Heart Circ Physiol. 313:H548-H557.
• Baker et al., 2019. Acoustic Pattern Recognition and Courtship Songs: Insights from Insects. Annu. Rev. Neurosci. 42:129–47
• Ni et al., 2021. The structure and function of ionotrophic receptors in Drosophila. Front Mol Neurosci 13: 638839.
• Naumov et al., 2019. Analysis of excitatory and inhibitory neuron types in the inferior colliculus based on Ih properties. J Neurophysiol 121: 2126–2139.
• Alluri et al., 2016. Phasic, suprathreshold excitation and sustained inhibition underlie neuronal selectivity for short-duration sounds. PNAS 113(13):E1927-35.
• Naud et al., 2015. Counting on dishabitulation:a circuit motif for internval counting and selectivity in the anurian auditory system. J Neurophysiol 114: 2804-2815.
• Baker et al., 2019. Acoustic Pattern Recognition and Courtship Songs: Insights from Insects. Annu. Rev. Neurosci. 42:129–47
• Zhang and Bean, 2021. Cannabinoid inhibition of murine primary nocioreceptors: Tight binding to slow inactivated states of Nav1.8 channels. J Neurosci 41(30): 6371-6387.
• MacDonald et al., 2021. A central mechanism of analgesia in mice and humans lacking the sodium channel, Nav1.7. Neuron 109: 1497-1512.
• Nunes and Kuner T, 2018. Axonal sodium channel NaV1.2 drives granule cell dendritic GABA release and rapid odor discrimination. PLoS Biol 16 (8): e2003816.
• Simms and Zaponi, 2014. Neuronal voltage-gated calcium channels: Structure, function, and dysfunction. Neuron 82: 24-45.
• Brunet, Gold, and Ngai, 1996. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron 17: 681-693.
• MacDonald et al., 2021. A central mechanism of analgesia in mice and humans lacking the sodium channel, Nav1.7. Neuron 109: 1497-1512.
• Zufall, Firestein, and Shepherd. 1991. Analysis of single cyclic nucleotide-gated channels in olfactory receptors cells. J Neurosci. 11(11): 3573-3580.
• Pietra et al. 2016. The Ca-activated Cl channel TMEM16B....J. Gen. Physiol. 148(4): 292-311.
• Benarroch, EE, 2015. Ion channels in nociceptors. American Acad Neurobiol. 84: 1153-1164
• Koroleva et al., 2020. Protective Effects of Hydrogen Sulfide Against the ATP-Induced Meningeal Nociception. Front. Cell. Neurosci. 14:266.
• Sadler et al., 2021. Transient receptor potential canonical 5 mediates inflammatory mechanical and spontaneous pain in mice. Sci Trans Medicine 13(595):eabd7702.
• Okada et al., 1998. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J. Biol. Chem. 273(17):10279-87.
• Papapoulodous and Verkman, 2013. Aquaporin water channels in the nervous system. Nature Rev Neurosci. 14(4):265-77.
• Murata et al., 2000. Structural determinants of water permeation through aquaporin-1. Nature. 407(6804):599-605
• Ozu et al., 2013. Human AQP1 Is a Constitutively Open Channel that Closes by a Membrane-Tension-Mediated Mechanism. Biophysical J. 104(1): 85-95.
• Nemeth-Cahalan and Hall. 2000. pH and Calcium Regulate the Water Permeability of Aquaporin 0*. 275(10):6777–6782
• Urban and Roth, 2015. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol . 55:399-417.
• Roth, 2018. DREADDS for Neuroscientists. Neuron 89:683-694.
• McCarthy et al., 2017. DREADD-induced silencing of the medial amygdala reduces the preference for male pheromones and the expression of lordosis in estrous female mice. Eur J Neurosci 46(4):2035-2046.
• Meissner-Bernard et al., 2019. Encoding of Odor Fear Memories in the Mouse Olfactory Cortex. Curr Biol 29(3):367-380.
• DiBenedictis et al., 2015. DREADD-Induced Silencing of the Medial Olfactory Tubercle Disrupts the Preference of Female Mice for Opposite-Sex Chemosignals(1,2,3). eNeuro. 2(5):ENEURO.0078-15.2015.
• Haumesser et al., 2017. Acute In Vivo Electrophysiological Recordings of Local Field Potentials and Multi-unit Activity from the Hyperdirect Pathway in Anesthetized Rats. JOVE 124 | e55940
• Broussard et al., 2016. Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus. Cell Reports 14, 1930–1939.
• Kodandaramaiah et al., 2012. Automated whole-cell patch-clamp electrophysiology of neurons in vivo Nature Methods 9(6): 585 -590.
• Sizemore et al., 2016. Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology. J Neurophysiol 115: 2124 –2146.
• . Aschauer et al., 2013. Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain. PloS1 Volume 8 | Issue 9 | e76310.
• Kim et al., 2017. Integration of optogenetics with complementary methodologies in systems neuroscience. Nat Rev Neurosci. 18(4): 222–235.
• Zhang et al., 2020. An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake. Nat. Comm. 11:6326.
• Xiao et al., 2021. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. 12:5249
• Lin and Schnitzer. 2016. Genetically encoded indicators of neuronal activity. Nature Neuroscience. 19(9): 1142.
• Kass et al., 2013. Changes in the Neural Representation of Odorants After Olfactory Deprivation in the Adult Mouse Olfactory Bulb Chem Senses. 38: 77–89.
• Bozza et al., 2004. In Vivo Imaging of Neuronal Activity by Targeted Expression of a Genetically Encoded Probe in the Mouse. Neuron. 42, 9–21.
• Li et al., 2005. Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin. PNAS. vol. 102
  no. 17
  6131–6136.
• Renauld et al., 2018. Cryo‑EM in drug discovery: achievements, limitations and prospects. Nature Reviews 17 | JULY 2018 | 471.
• Doyle et al., 1998. The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity. Science. VOL. 280: 69.
• Ruso et al., 2017. Structure of isolated Z-disks from honeybee flight muscle. J Muscle Res Cell Motil 38:241–250.
• Adams et al., 1969. Structure of Rhombohedral 2 Zinc Insulin Crystals. Nature. 224: 491.
• Zhang et al., 2012. Structural basis for calmodulin as a dynamic calcium sensor. Structure. 20(5): 911–923.

Archived Resources for Fall 2018 Class



• Bean B. 2007. The action potential in mammalian central neurons. Nature Reviews 8: 451-465.
• Fundamental Physiological Recordings. Chapters 1-3; Aidley.
• Background on Electricity. Chapters 1, 6-7; Gerrish.
• Watch Rod MacKinnon's Nobel Lecture on Potassium Channels - Click Here
• Tian et al., 2014. Potassium channels: Structures, Diseases, and Modulators. Chem Bio. Drug. Des. 83:1-26.
• MacKinnon, R., 2003. Potassium channels. FEBS Letters 555: 62-65.
• Guan et al., 2018. Functional roles of Kv1-mediated curents in genetically idientified subtypes of pyramidal neurons in layer 5 of mouse somatosensory cortex. J. Neurophysiol. 120:394-408.
• Hoshi et al., 1990. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250(4980):533-538.
• Fernandez-Marino et al., 2018. Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel. Nature Struct. Mol. Biol. 25(4):320-326.

Archived Resources from Fall 2014 Class



• Bean B. 2007. The action potential in mammalian central neurons. Nature Reviews 8: 451-465.
• Fundamental Physiological Recordings. Chapters 1-3; Aidley.
• Background on Electricity. Chapters 1, 6-7; Gerrish.
• Watch Rod MacKinnon's Nobel Lecture on Potassium Channels - Click Here
• Talwar and Lynch. 2014. Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: Implications for drug discovery. Int. J. Biochem. Cell Biol. 53: 218-223.
• Palma et al., 1998. Effects of Zn2+ on wild and mutant neuronal alpha 7 nicotinic receptors. PNAS 95: 10246-10250.
• Rosenmund et al., 1998. The tetrameric structure of a glutamate receptor channel. Science. 280: 1596-1601.
• Dixon et al., 2014. GABA A receptor alpha and gamma subunits shape synaptic currents via different mechanisms. J. Biol. Chem. 289: 5399-5411.
• KATP channels as molecular sensors of cellular metabolism Nichols 440: 470-476.
• Han et al., 1996. Indentification and properties of an ATP-sensitive K+ current in rabbit sin-atrial node pacemaker cells. J. Physiol. 490: 337-350.
• Gloyn et al., 2004. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. New Eng J Med. 350(19): 1838-1849.
• Miki et al., 1998. Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. PNAS 95: 10402-10406.
• Catterall. 2000. From ionic currents to molecular mechanisms: The structure and function of voltage-gated ion channels. Neuron 26: 13-25.
• Lacroix et al., 2013. Molecular bases for the asynchornous activation of sodium and potassium channels required for nerve impulse generation. Neuron 79: 651-657.
• Marionneau et al., 2012. The sodium channel accessory subunit NavB1 regulates neuronal excitability through modulation of repolarizing voltage-gated K+ channels. J Neurosci 32(17): 5716-5727.
• Weiss et al. 2011. Loss of function mutations in sodium channel naV1.7 cause anosmia.
• Gaonzalez et al., 2012. K+ Channels: Function-Structural Overview. Comprehensive Physiol. 2:2087-2149.
• Hibino et al., 2010. Inward rectifying potassium channels: Their structure, function, and physiological roles. Phys. Reviews 90:291-366.
• Faber and Sah. 2002. Physiological role of ca-activated K currents in the rat lateral amygdala. J Neurosci. 22(5): 1618-1628..
• Li et al., 2013. Intracellular ATP binding is required to activate the slowly activating K+ chanel I ks. PNAS 110(47): 18922-18927.
• Borin et al., 2014. Inward rectifer potassium (Kir) current in dopaminergic periglomerular neurons of the mouse olfactory bulb. 8(223): 1-15.
• Catterall, W. 2011. Voltage-gated calcium channels. Cold Spring Harbor Perspectives Biology
• Tang et al. 2014. Structural basis for Ca2+ selectivity of a voltage-gated calcium channel. Nature. 505(7481): 56-61.
• Weiss et al., 2014. Altered synaptic transmission at olfactory and vomeronasal nerve terminals in mice lacking N-type calcium channel Cav2.2. Eur J Neurosci Sept 5 Epup ahead of print
• DeCaen et al., 2013. Direct recording and molecular identification of the calcium channel of primary cilia. Nature 504(7479):315-318.
• Jentsch et al., 2002. Molecular structure and physiological function of chloride channels. Physiol. Rev. 82: 503-568.
• Billig et al., 2011. Ca2+-activated Cl- currents are dispensable for olfaction. Nature Neurosci 14(6): 763-769.
• Lin et al., 2014. A single amino acid substitution in CFTR converts ATP to an inhibitory ligand. J Gen Physiol. 144(4):311-320.
• Bennetts and Parker, 2013. Molecular determinants of common gating of a CLC chloride channel. Nature Comm. 4:2507.
• Hamill et al., 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
• Sakmann and Neher. Single Channel Analysis, Chapter 1, A Practival Guide to Patch-Clamping, pages 1-29.
• Sakmann and Neher. Single Channel Analysis, Chapter 3, Guide to Data Acquisition and Analysis, pages 53-90.
• Sakmann and Neher. Single Channel Analysis, Chapter 18, The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms, pages 397-479.
• Sakmann and Neher. Single Channel Analysis, Chapter 19, Fitting and Statistical Analysis of Single-channel Records, pages 483-585.
• Fenno et al., 2011. The development and application of optogentics. Ann Rev Neurosci. 34: 389-412
• Tischer and Weiner, 2014. Illuminating cell signalling with optogenetic tools. Nature Reviews Mol Cell Biol 15: 551-558.
• Yizhar et al., 2011. Optogenetics in neural systems. Neuron 71: 9-15.
• Jia et al., 2011. Stimulating cardiac muscle by light: Cardiac optogenetics by cell delivery. Circ Arrhythm Electrophysiol. 4: 753-760.
• Prigge et al., 2012. Color-tuned channelrhodopsins for multiwavelength optogenetics. 287: 31804-31812.
• Boada et al., 2014. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. PAIN In Press
• Economo et al., 2010. Dynamic Clamp: Alternation of response properties and creation of virtual relalities in neurophysiology. J. Neurosci 30(7): 2407-2413.
• Prinz and Marder. 2004. The dynamic clamp comes of age. TRENDS In Neurosci 27(4).
• Tucker K.R. et al., 2012. Pacemaker rate and depolarization block in nigral dopamine neurons: A somatic sodium channel balancing act. J. Neurosci 32(42): 14519-14531.
• Workman et al., 2012. Transient outward K current reduction prolongs action potentials and promotes afterdepolarizations: a dynamic clamp study in human and rabbit cardiac atrical myocyes. J Physiol. 590.17: 4289-4305.
• Tabak et al., 2011. Fast activating voltage- and Ca-dependent K conductance promotes bursting in pitutary cells: a dynamic clamp study. J Neurosci. 31(46): 16855-16863.
• Logothetis, NK. 2008. What we can do and what we cannot do with fMRI. Nature Reviews 453: 869-879.
• Kulkarni et al., 2012. Imaging evolutionary conserved neural networks: Preferential activation of the oflactory system by food-related odor. Behav Brain Res 230: 201-207.
• Sun et al., 2014. The neural signature of satiation is associated with ghrelin response and triglyceride metabolism. Phys and Beh pub before press
• Li et al., 2014. Complex relationship between BOLD-fMRI and electrophysiological signals in different olfactory bulb layers. Neuroimage 95: 29-38.
• Kang et al., 2013. Breaking the barriers in membrane protein crystallograph. International J of Bioch Cell Biol 25: 636-644.
• Long et al., 2005. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science 309: 897.
• Sauguet et al., 2014. Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. PNAS 111(3): 966-971.
• Kvist et al., 2013. Crystal structure and pharmacological characterization of a novel NMDA receptor antagonist at the GluN1 glycine binding site. J Biol. Chem. 288: 33124-33135.
• Long and Lee. 2012. Intracellular recording in behaving animals. Curr Opin in Neurobiol. 22: 34-44.
• Khodagholy et al., 2013. In vivo recordings of brain activity using organie transistors. Nature Communications. 4: 1575.
• Fukunaga et al., 2014. Independent control of gamma and theta activity by distinct interneuron networks in the olfactory bulb. Nature Neurosci 17(9): 1208.
• INSERT Zhenbo's Selection Here

Archived Resources from Fall 2011



• Catterall W.A. 2000. From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels. Neuron 26: 13-25.
• Volkers et al., 2011. Nav1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome. Eur J Neurosci epup ahead of print: 1-8.
• He and Soderlund. 2010. Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currentsand Nav1.7 sodium channels. 469: 268-272.
• Rowe et al. Isolation and characterization of CvIV4: A pain inducing alpha-scorpion toxin. PLoS One 6(8): e23520.
• Weiss et al., 2011. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature 472: 186-192. - Commentary on the Nature article
• Choe, S. Potassium channel structures. Nature Reviews 3: 115-121.
• Yamamoto et al., 2011. Suppression of a neocortical potassium channel activity byintracellular amyloid B and its rescue with Homer1a. J. Neurosci. 31(31): 11100-11109.
• Choi et al., 2011. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertention. Science 331: 768-772.
• Mirkovic and Wickman, 2011. Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene. Neurosci. e pub ahead of press.
• Billig et al., 2011. Ca2+-activated Cl- currents are dispensable for olfaction. Nature Neurosci 14(6): 763-771.
• Dutzler et al., 2003. Gating the selectivity filter in ClC chloride channels. Science 300: 108-112.
• Valdivieso et al. Measurement of cystic fibrosis transmembrane conductance regulator activity using fluorescence spectrophotometry. Anal Biochem 418: 231-237.
• Suzuki et al., 2006. Diversity of Cl- channels. Cell Mol Life Scie 63: 12-24.
• Jentsch et al. 2002. Molecular Structure and physiological function of chloride channels. Physiol Review 82: 503-568. USE AS ADDITIONAL RESOURCE; VERY DETAILED.
• Makino et al., 2011. Enhanced synaptic plasticity in mice with phosphomimetic mutation of the GluA1 AMPA receptor. PNAS 108(20): 8450-8455.
• Kelly et al., 2009. Synaptic mGluR activation drives plasticity of calcium-permeable AMPA receptors. Nature Neurosci. 12(5): 593-601.
• Karakas et al., 2011. Subunit arrangement and phenylethanolamine biding in GluNa/GluN2B NMDA receptors. Nature 475: 249-254.
• Chaudhry et al., 2009. Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions. PNAS 106(30): 12329-12334.
• Baenziger et al., 2011. 3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels. Neuropharm 60: 116-125.
• Kim et al., 2011. Requirement of calcium-activated chloride channels in the activation of mouse vomeronasal neurons. Nature DOI: 10.1038, 7 pages.
• Riccio et al., 2009. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell 137: 761-772.
• Liu et al. 2007. In vivo identification and manipulation of the Ca2+ selectivity filter in the drosophila transient receptor potential channel. J. Neurosci. 27(3): 604-615.
• Montell, C. 2001. Physiology, phylogeny, and functions of the TRP superfamily of cation channels. Science STKE. 17 pages.
• Hendrich et al., 2008. Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin. PNAS 105(9): 3628-3633.
• Fuller et al., 2010. Molecular mechanism of calcium channel regulation in the fight-or-flight response. Science Signaling 3(141): ra70, 9 pages.
• Condliffe et al., 2010. Endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons. J. Biol. Chem. 285(32): 24968-24976.
• Catterall, W.A. 2011. Voltage-gated calcium channels. Cold Spring Harbor Perspect Biol. 3: a003947, 24 pages.
• Hamill et al., 1981. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391: 85-100.
• Sarkisov and Wang. Combining uncaging techniques with patch-clamp recording and optical physiology. Neuroscience Methods 38: 149-201.
• Callaway and Yuste. 2002. Stimulating neurons with light. Cur Opin Neurobiol 12: 587-592.
• Harvey and Svoboda. 2007. Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature 450(20): 1195-1202.
• Witten et al., 2010. Cholinergic interneurons control local circuit activity and cocaine conditioning. Science 330: 1677-1681.
• Kravitz et al., 2010. Regulation of parkinsonian motor behaviors by optogentic control of basal ganglia circuitry. Nature 466: 622-629.
• Sakmann and Neher. Single Channel Analysis, Chapter 1, A Practival Guide to Patch-Clamping, pages 1-29.
• Sakmann and Neher. Single Channel Analysis, Chapter 3, Guide to Data Acquisition and Analysis, pages 53-90.
• Sakmann and Neher. Single Channel Analysis, Chapter 18, The Principles of the Stochastic Interpretation of Ion-Channel Mechanisms, pages 397-479.
• Sakmann and Neher. Single Channel Analysis, Chapter 19, Fitting and Statistical Analysis of Single-channel Records, pages 483-585.
• Kralik, et al., 2001. Techniques for long-term multisite neuronal ensemble recordings in behaving animals. METHODS 25: 121-150.
• Ding et al., 2011. Cortical excitation and inhibition following focal traumatic brain injury. J Neurosci 31(40): 14-85-14094.
• Roitman et al., 2005. Nucleus accumbens neurons are innately tuned for rewarding and aversive taste stimuli, encode their predators, and are linked to motor output. Neuron 45: 587-597.
• Kravitz et al., 2010. Mordel et al., 2011. Activation of glycine receptor phase-shirts the ciracadian rhythm in neuronal activity in the mouse suprachiasmatic nucleus. J Physiol 589.9: 2287-2300.
• Robinson et al., 2003. Detecting subsecond dopamine release with fast-scan cyclic voltammetry in vivo. Clin Chem 49(10): 1763-1773.
• Fulton et al., 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow. JBC 286(11): 9360-9372.
• Garret et al., 2008. Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science 321: 1690-1694.
• Bender et al., 2010. Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation. Neuron 68: 500-511.
• Whole-cell recording in vivo. 2007. Neurophysiology Supplement 38 Current Protocols in Neuroscience. ed. John Wiley and Sons 6.22.1-6.22.15.
• Poo and Isaacson. 2011. A major role for intrcortical circuits in the strength and tuning of odor-evoked excitation in olfactory cortex. Neuron 72: 41-48.
• Yartsev et al., 2011. Grid cells without theta oscillations in the entorhinal cortex of bats. Nature 479: 103-107.
• Kopp-Scheinpflug et al., 2003. Decreased temporal precision of auditory signaling in KCNA1-null mice: an electrophysiological study in vivo. J Neurosci. 23(27): 9199-9207.
• Opella et al., 1999. Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR. Nature Struct Biol 6(4): 374-379.
• Li et al., 2007. Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel. Biochimica Biophysica Acta 1768: 3162-3170
• Osawa et al., 2009. Evidence for the direct interaction of spermine with the inwardly rectifying potassium channel. J Biol Chem 284(38): 26117-26126.
• Opella et al., 2002. Structure determination of membrane proteins by NMR spectroscopy. Biochem Cell Biol 80: 597-604.

Archived Resources from Fall 2007



• Catterall et al., 2005. Nominclature and Structure-Function Relationships of Voltage-Gated Sodium Channels.Pharm Reviews 57(4): 397-409.
• Bendahhou et al., 2007. Role of hydrophobic residues in the voltage sensors of the voltage-gated sodium channel. BBA 1768: 1440-1447.
• Li and Tomaselli. 2004. Using the deadly u-conotoxins as probes of voltage-gated sodium channels. Toxicon. 44: 117-122.
• Malik et al., 2006. Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway. Am J Physiol. Renal Physiol. 290: F1285-F1294.
• Sands and Sansom. 2007. How does a voltage sensor interact with a lipid bilayer? Simulations of a potassium channel domain. Structure 15: 235-244.
• Oliva et al. 2005. Slow inactivation in voltage gated potassium channels is insesitive to the binding of pore occluding peptide toxins. Biophys. J.89: 1009-1019.0
• Kurata and Fedida, 2005. A structural interpretation of voltage-gated potassium channel inactivation. Prog. Biophys. & Mol. Biol. 92: 185-208.
• Long et al., 2005. Crystal structure of a mammalian voltage-dependent Shaker family K+>channel. Science. 309: 897-903.
• Kleene, S and R. Gestleland. 1991. Calcium-activated chloride conductance in frog olfactory cilia. J. Neurophysiol. 11(11): 3624-3629.
• Yin et al., 2007. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Am J Physiol. Cell Physiol. 292: C269-C277.
• Bennetts et al., 2007. Inhibition of skeletal muscle CLC-1 chloride channels by low intracellular pH and ATP. J Biol. Chem. Published online 10 August.
• Suzuki et al., 2006. Review: Diversity of Cl- Channels. Cell. Mol. Life Sci. 63: 12-24.
• Grutter et al., 2005. Molecular tuning of fast gating in pentameic ligand-gated ion channels. PNAS 102(50): 18207-18212.
• Rosenmund et al., 1998. The tetrameric structure of a glutamate receptor channel. Science 280: 1596-1599.
• Roberts and Evans. 2007. Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors. J. Neurosci. 27(15): 4072-4082.
• Craven and Zagotta. 2006. REVIEW: CNG and HCN Channels: Two Peas, One Pod. Annual Rev. Physiol. 68: 375-401.
• Lucas et al. 2003. A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40:551-561.
• Nache et al., 2005. Activation of olfactory-type cyclic nucleotide-gated channels is highly cooperative. J Physiol. 569.1: 91-102.
• Hamada et al., 2003. Three-dimensional rearrangements within inositol 1,4,5-trisphosphate receptor by calcium. J Biol. Chem. 278(52): 52881-52889.
• Ion channels for communication between and within cells. Nobel Lecture, December 1991.
• Elementary steps in synaptic transmission revealed by current through single ion channels. Nobel Lecture, December 1992.
• Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflugers Arch 391(2): 85-100.
• Webster et al. 2006. Amyloid peptides mediate hypoxic increase of L-type Ca2+ channels in central neurones. Neurbiol of Aging 27: 439-445.
• Wahl-Schott et al., 2006. Switching off calcium-dependent inactivation in L-type calcium channels by an autoinhibitory domain. PNAS 103(42): 15657-15662.
• Yaari et al., 2007. Recruitment of apical dendritic T-type Ca2+ channels by backpropagating spikes underlies de novo intrinsic bursting in hippocampal epileptogenesis. J. Physiol. 580.2: 435-450.
• Hogan Q. H. 2007. Role of decreased sensory neuron membrane calcium currents in the genesis of neuropathic pain. Croat Med J. 48: 9-21.
• Riera et al., 2007. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am J Physiol. REgul. Integr. Comp. Physiol. 293: R626-R634.
• McGann et al., 2005. Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons. Neuron 48: 1039-1053.
• Lowe G. 2003. Flash photolysis reveals a diversity of ionotrophic glutamate receptors on the mitral cell somatodendritic membrane. J. Neurophysiol. 90: 1737-1746.
• Zochowski et al., 2000. Concepts in Imaging and Microscopy: Imaging membrane potential with voltage-sensitive dyes. Biol. Bull. 198: 1-21.
• Oka et al., 1999. A new planar multielectrode array for extracellular recording: application to hippocampal acute slice. J. Neurosci. Methods. 93: 61-67.
• Egert et al. 1998. A novel organotypic long-term culture of the rat hippocampus on substrate-integrated multielectrode arrays. Brain Res. Protocols 2: 229-242.
• Granados-Fuentes et al., 2004. Olfactory bulb neurons express functional, entrainable, circadians rhythms. Eur. J. Neurosci. 19: 898-906.
• Dobbins et al., 2007. Chronically recording with a multi-electrode array devide in the auditory cortex of an awake ferret. J. Neurosci. Met. 161: 101-111.
• Hochberg et al., 2006. Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442: 164-171.
• Starace and Bezanilla. 2001. Histidine scanning mutagenesis of basic residues of the S4 segment of the Shaker K+ channel. J Gen. Physiol. 117: 469-490.
• Mori and Ito. 2001. An essential amino acid residue in the protein translocation channel revealed by targeted random mutageneiss of SecY. PNAS 98(9): 5128-5133. .
• Mansour et al. 1997. Key residues defining the u-Opiod receptor binding pocket: a site-directed mutagenesis study. J. Neurochem. 68: 344-353.
• Beene et al., 2003. Unnatural amino acid mutagenesis in mapping ion channel function. Cur. Opin. Neurobiol. 13: 264-270.
• Berggard et al., 2007. Methods for the detection and analysis of protein-protein interactions. Proteomics 7: 2833-2842.
• Shoemaker and Panchendo. 2007. Deciphering protein-protein interactions. Part II. Computational methods to predict protein and domain interaction partners. PLoS Computational Biology 3(4): 595-
• Borisenko et al., 2003. Simultaneous optical and electrical recording of single gramicidin channels. Biophysical J 84: 612-622.
• Piston and Kremers. 2007. Fluorescent Protein FRET: the good, the bad, and the ugly. TRENDS in Biochemical Sciences 32(9): 407-414.
• Jin et al., 2003. Structural basis for partial agonist action at ionotrophic glutamate receptors. Nature Neurosci. 6(8): 803 - 810.
• Swartz, KJ. 2004. Towards a structural view of gating in potassium channels. Nature Neurosci. 5: 905-916.
• Moretti et al., 2004. Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands. J. Struct. Biol. 145: 205- 215.
• Furukawa et al., 2005. Subunit arrangement and function in NMDA receptors. Nature. 428: 185-192.

Archived Resources from Fall 2005 Class



• Waxman et al., 2004. Na Channel expression along axons in multiple sclerosis and its models. TRENDS Pharm. Sci. 25(11): 584-591.
• Chang et al., 2004. A novel SCN5A mutation manifests as a maligant form of long QT syndrome with perinatal onset of tachycardia/bradycardia. Cardiovas. Research 64: 268-278.
• Zhao et al., 2004. A gating hinge in Na+ channels: A molecular switch for electrical signaling. Neuron. 41: 859-865.
• Gandhi et al., 2003. The orientation and molecular movement of a K+ channel voltage-sensing domain. Neuron 40: 515-525.
• Doyle et al., 1998. The structure of the potassium channel: Molecular basis of K+ conduction and selectivity. Science 280: 69-77.
• Aggarwal and MacKinnon, 1996. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron 16: 1169-1177.
• Dutzler et al., Gating the selectivity filter in CLC chloride channels. Science 300: 108-113.
• Maduke et al., 2000. A decade of CLC Chloride channels: Structure, mechanism, and many unsettled questions. Annu. Rev. Biophys. Biomol. Struct.
• Perez-COrnego. 2004. Regulation of Ca2+-activated chloride channels by cAMP and CFTR in parotid acinar cells. BBRC 316: 612-617.
• Pusch, M. 2004. Structural insights into chloride and proton-mediated gating of CLC chloride channels. Biochemistry. 43(5): 1135-1145
• Unwin, N. 2003. Structure and action of the nicotinic acetylcholine receptor explored by electron microscopy. FEBS Letters 555: 91-95.
• Gally et al., 2004. A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans
• Gotti and Clementi. 2004. Neuronal nicotinic receptors: from structure to pathology. Prog. in Neurobiol. 74: 363-396.
• Cormier et al., 2004. Long-term exposure to nicotine modulates the level and activity of acetylcholine receptors in white blood cells of smokers and model mice. Mol. Pharmacol. 66: 1712-1718.
• Matulef and Zagotta. 2003. Cyclic nucleotide-gated ion channels. Annu. Rev. Cell Dev. Biol.19: 23-44.
• Zheng and Zagotta. 2004. Stoichiometry and assembly of olfactory cyclic nucleotide-gated channels.Neuron. 42: 411-421.
• Krajewski et al. 2003. Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+ calmodulin inhibition. J. Neurosci. 23(31): 10100-10106.
• Brady et al., 2004. Functional role of lipid raft microdomains in cyclic nucleotide-gated channel activation. Mol. Pharmacol. 65(3): 503-511.
• Catterall. 2000. Structure and regulation of voltage-gated Ca2+ channels. Annu. Rev. Cell Dev.>Biol. 16: 521-555.
• McGee et al. 2004. Calcium channel function regulated by the SH3-GK module in Beta Subunits. Neuron. 42: 89-99.
• Cibulsky and Sather. 2003. Control of ion conduction in L-type Ca2+ channels by the concerted action of S5-6 regions. Biophys. J. 84: 1709-1719.
• Kim et al., 2004. Identification of the components controlling inactivation of voltage-gated Ca2+ channels. Neuron. 41: 745-754.
• Ion channels for communication between and within cells. Nobel Lecture, December 1991.
• Elementary steps in synaptic transmission revealed by current through single ion channels. Nobel Lecture, December 1992.
• Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches. Pflugers Arch 391(2): 85-100.
• Tertyshnikova and Fein. 1998. Inhibition of inositol 1,4,5-trisphosphate-induced Ca2+ release by cAMP-dependent protein kinase in a living cell. PNAS 95: 1613-1617.
• Eerbeek et al., 2004. Ratiometric intracellular calcium imaging in the isolated beating rat heart using indo-1 fluorescence. J Applied Physiol. 97: 2042-2050.
• Takahashi et al., 1999. Measurement of intracellular calcium. Physiol. Reviews 79 (4): 1089-1125.
• Segev et al., 2004. Recording spikes from a large fraction of the ganglion cells in a retinal patch. Nature Neuroscience. 7(10): 1155-1162.
• Christensen et al., 2000. Multi-unit recordings reveal context-dependent modulation of synchrony in odor-specific neuroal ensembles. Nature Neuroscience 3(9): 927-931.
• Rennaker et al., 2005. An economical multi-channel cortical electrode array for extended periods of recording during behavior. 142: 97-105.
• Oberleithner et al., 1997. Structural activity of a cloned potassium channel (ROMK1) monitored with the atomic force microscope: The "molecular-sandwich" technique. PNAS 94: 14144-14149.
• Jena et al., 2003. Structure and composition of the fusion pore. Biophysical Journal 84: 1337-1343.
• Garavaglia et al., 2004. Membrane thickness changes ion-selectivity of channel-proteins. Cell Physiol. Biochem. 14: 231-240. Edwardson adn Henderson. 2004. Atomic force microscopy and drug discovery. DDT 9(2): 64-71.
• Jiang et al., 2003. X-ray structure of a voltage-dependent K+ channel. Nature 423: 33-41.
• Hubbard, S.R. 1997. Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16(18): 5573-5581.
• Betzel et al., 2001. Structure of a serine protease proteinase K from Tritirachium album limber at 0.98 Angstrom Resolution. Biochemistry 40: 3080-3088.