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Date:
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Lecture#
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Topic:
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Text:
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24 Aug T |
1
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Introduction Basic Electricity |
Hille Chapter 1; Primary Literature |
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Course Overview; Selection of Assignments definitions and calculations for electricity |
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27 Aug F |
2 |
Electrical Circuits |
Gerrish et al. Chapters 1 & 6 |
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definitions and calculations for circuits |
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31 Aug T |
3 |
Measuring Biological and Optical Signals |
Aidley Chapters 1-3 |
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amplifiers and voltage-clamp circuits, definitions of optical probes and equipment |
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3 Sept F |
4 |
Ion Movement in Excitable Cells |
Hille Chapter 2 |
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Nernst potential; Goldman-Hodgkin-Katz,
physical laws that dictate ion movement |
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7 Sept T |
5
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Electrical Properties of the Excitable Membrane |
Hille Chapter 3 |
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biological circuits,
membrane conductance, parallel conductance model, IV relationships |
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10 Sept F |
6
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Channel Presentation #1 Discussion
Leader: Lily
Barret |
Primary Literature; Hille Chapter 6 |
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Potassium Channels |
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14 Sept T |
7
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Electrical Properties of the Excitable Membrane |
Hille Chapter 3 |
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parallel conductance model, IV relationships |
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17 Sept F |
8
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Channel Presentation #2 Discussion Leader: Emily
Moriarty-Lemon |
Primary Literature; Hille Chapter 7 |
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Transmitter or Ligand-gated Channels |
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21 Sept T |
9 |
Functional Properties of Dendrites
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Primary Literature |
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electrotonic properties, nonisopotential cells (cylinders), rall model for neurons |
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24 Sept F |
10 |
Channel
Presentation #3 Discussion Leaders: Meizhu Qi |
Primary Literature; Hille Chapter 4 |
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Sodium Ion Channels |
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28 Sept T |
11
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Nonlinear Properties of Excitable Membranes |
Hille Chapter 2 |
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membrane rectification, Hodgkin & Huxley gate model, constant field model |
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1 Oct F |
12
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Channel Presentation #4 Discussion Leaders: Destinee
Gatlin |
Primary Literature; Hille Chapter 3, 9 |
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Calcium and Non-selective Ion Channels |
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5 Oct T |
13 |
Squid Giant Axon classical voltage-clamp, H
& H model, propagating & nonpropagating AP,
gating currents |
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8 Oct F |
14 |
Channel
Presentation #5 Trp Channels and Nociceptors Discussion Leaders: Ryan Ochoa |
Primary Literature; Hille Chapter 5 |
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12 Oct T |
15 |
Channel
Presentation #6 Discussion Leader: Ashley Loeven |
Primary Literature; Hille Chapter 4 |
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Aquaporins |
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15 Oct F |
16
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Biophysical Methods Presentation #1 |
Primary Literature |
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Patch-clamp Electrophysiology Discussion Leader: Debi Fadool |
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19 Oct T |
17 |
Molecular Structure and Unitary
Currents of Ion Channels |
Hille Chapter 13, Sakmann/Neher Chapter 3,18, and 19 |
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molecular structure,
patch-clamp records of single-channel currents |
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22 Oct F |
18 |
Stochastic Analysis of Single-Channel Function I |
Sakmann/Neher Chapter 18 and 19 |
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statistical analysis of single channel records, probability density functions, Markov processes, kinetic schemes, channel agonists & antagonists
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26 Oct T |
19
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Stochastic Analysis of Single-Channel Function II |
Sakmann/Neher Chapter 18 and 19 |
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statistical analysis of single channel records, probability density functions, Markov processes, kinetic schemes, channel agonists & antagonists
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29 Oct F |
20 |
Biophysical Methods Presentation #2 Discussion
Leader: Destinee
Gatlin |
Primary Literature |
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DREADDs |
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2 Nov T |
21
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Synaptic Transmission: Presynaptic Mechanisms |
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chemical transmission, quantum hypothesis, use-dependent synaptic plasticity |
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5 Nov F |
22
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Synaptic Transmission: Calcium and Transmitter Release |
pp. 323-356 |
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calcium
hypothesis, molecular mechanisms of release, calcium domains |
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9 Nov T |
23 |
Synaptic Transmission: Postsynaptic Mechanisms |
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synaptic conductances and reversal potentials, diversity of neurotransmitters,
electrical synapses, dendritic spines |
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12 Nov F |
24 |
Biophysical Methods Presentation #3 Discussion Leader: Paula Nieto & Lily Barret |
Primary Literature |
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In Vivo Electrophysiology and Viral Infection Strategies |
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16 Nov T |
25
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Extracellular Field Recordings, Cellular
Neurophysiology of |
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potentials in a volume conductor, classification of fields, current source-density analysis |
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19 Nov F |
26 |
Biophysical Methods Presentation #4 Discussion Leader: Ryan Ochoa & Meizhu Qi |
Primary Literature
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Voltage Sensitive Dyes, Optical Sensors, and Optogenetics |
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23 Nov T |
27 |
Biophysical Methods Presentation #5 Discussion Leaders: Ashley Loeven |
Primary Literature |
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X-ray Crystallography/Cryo EM |
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26 Nov F |
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Thanksgiving Holidays |
No Classes |
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30 Nov T |
28 |
Learning and Memory |
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spine shape and synaptic
plasticity, Hebb rule, cellular mechanisms of LTP & LTD, correlation
matrix |
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3 Dec F |
29 |
Ion Channel Presentation/Methods Discussion Leader: Paula Nieto |
Primary Literature |
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Nucleopore Complex |
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7 Dec T |
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Final Examination (Week of 10 – 14 Dec) 7:30 am to 10:30 am |
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