Research Articles


Yang SA, Portilla JM, Mihailovic S, Huang YC, Deng WM. 2019. Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment. Dev Cell.

Lo PK, Huang YC, Corcoran D, Jiao R, Deng WM. 2019. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation. J Cell Sci.


Yang SA, Deng WM. 2018. Serrate-Notch Signaling Regulates the Size of the Progenitor Cell Pool in Drosophila Imaginal Rings. Genetics.

Huang YC, Moreno H, Row S, Jia D, Deng WM. 2018. Germline silencing of UASt depends on the piRNA pathway. J Genet Genomics.


Shu Z, Huang YC, Palmer WH, Tamori Y, Xie G, Wang H, Liu N, Deng WM. 2017. Systematic analysis reveals tumor-enhancing and -suppressing microRNAs in Drosophila epithelial tumors. Oncotarget. 8 (65):108825-108839

Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, Liang X, Liu J, Li C, Lindstrom-Battle A, Lam SM, Shui G, Deng WM, Jiao R. 2017. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila Developmental Cell. 43 (1):99-111

Zouaz A, Auradkar A, Delfini MC, Macchi M, Barthez M, Ela Akoa S, Bastianelli L, Xie G, Deng WM, Levine SS, Graba Y, Saurin AJ. 2017. The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription. EMBO J. 36(19):2887-2906

Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. 2017. The m6A pathway facilitates sex determination in Drosophila. Nature Communication. 8:15737

Shu Z, Deng WM. 2017. Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development. G3. 7(3):1049-1060

Xie G, Chen H, Jia D, Shu Z, Palmer WH, Huang YC, Zeng X, Hou SX, Jiao R, Deng WM. 2017. The SWI/SNF complex protein Snr1 is a tumor suppressor in Drosophila imaginal tissues. Cancer Res. 15;77(4):862-873


Tamori Y, Suzuki E, Deng WM. 2016. Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment. PLoS Biol. 1;14(9):e1002537.

Jia D, Bryant J, Jevitt A, Calvin G, Deng WM. 2016. The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs. J Genet Genomics. 5:12328

Jia D, Xu Q, Mio W, Deng WM. 2016. Automatic stage identification of Drosophila egg chamber based on DAPI images. Scientific Report. 6:18850.

Lo PK, Huang YC, Poulton JS, Leake N, Palmer WH, Vera D, Xie, Klusza S, Deng WM. 2016. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila. Develompental Biology. 412 (1): 57-70


Jia D, Soylemez M, Calvin G, Bornmann R, Bryant J, Hanna C, Huang YC, Deng WM. 2015. A large-scale in vivo RNAi screen to identify genes involved in Notch-mediated follicle cell differentiation and cell cycle switches. . Scientific Reports. 5:12328

Zhang H, Li C, Chen H, Wei C, Dai F, Wu H, Dui W, Deng WM, Jiao R. 2015. SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila. Cell Research. 25(1):93-109

Jia D, Huang YC, Deng WM. 2015. Analysis of Cell Cycle Switches in Drosophila Oogenesis. Methods in Molecular Biology. 1328:207-16.


Palmer WH, Jia D, Deng, WM. 2014. Cis-interactions between Notch and its ligands block ligand-independent Notch activity. eLife. 3:e04415.

Yu Z, Chen H, Liu J, Zhang H, Yan Y, Zhu N, Guo Y, Yang B, Chang Y, Dai F, Liang X, Chen Y, Shen Y, Deng WM, Chen J, Zhang B, Li C, Jiao R. 2014. Various applications of TALEN- and CRISPR/Cas9-mediated homologous recombination to modifytheDrosophilagenome. Biology open. 3(4):271-80.

Xie G, Yu Z, Jia D, Jiao R, Deng WM. 2014. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. Journal of Cell Science. 127(Pt 17):3830-9.

Jia D, Tamori Y, Pyrowolakis G, Deng WM. 2014. Regulation of broad by the Notch pathway affects timing of follicle cell development. Developmental Biology. 392(1): 52-61.


Klusza S, Novak A, Figueroa S, Palmer W, Deng WM. 2013. Prp22 and Spliceosome Components Regulate Chromatin Dynamics in Germ-Line Polyploid Cells. PLoS ONE. 8(11):e79048.

Yu Z, Wu H, Chen H, Wang R, Liang X, Liu J, Li C, Deng WM*, Jiao R.* 2013. CAF-1 promotes Notch signaling through epigenetic control of target gene expression during Drosophila development. Development. 140(17): 3635-4. (*equal contributing co-corresponding authors)

Tamori Y, Deng WM. 2013. Tissue Repair through Cell Competition and Compensatory Cellular Hypertrophy in Postmitotic Epithelia. Developmental Cell. 25(4): 350-363.

Huang YC, Poulton J, Smith L, Deng WM. 2013. The microRNA miR-7 regulates Tramtrack69 in a developmental switch in Drosophila follicle cells. Development. 140(4): 897-905.

Tian AG, Tamori Y, Huang YC, Toledo Melendez N, Deng WM. 2013. Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking. Developmental Biology. 373(2): 349-58.


Heck BW, Zhang B, Tong X, Deng WM, Tsai CC. 2012. The transcriptional corepressor SMRTER influences both Notch and ecdysone signaling during Drosophila development.Biology open. 1(3): 182-196.

Liu J, Li C, Huang P, Wu H, Wei C, Zhu N, Shen Y, Chen Y, Deng WM*, Jiao R*. 2012. Efficient and Specific Modifications of the Drosophila Genome by Means of an Easy TALEN Strategy. Journal of Genetics and Genomics. 39: 209-215. (*equal contributing co-corresponding authors)


Deng WM. 2011. Molecular genetics of cancer and tumorigenesis: Drosophila models. Journal of Genetics and Genomics. 38(10): 429-30.

Poulton J, Huang YC, Smith L, Sun JJ, Leake N, Schleede J, Stevens L, Deng WM. 2011. The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. Development. 138(9): 1737-45.


Tamori Y, Bialucha CU, Tian AG, Kajita M, Huang YC, Norman M, Harrison N, Poulton J, Ivanovitch K, Disch L, Liu T, Deng WM*, Fujita Y*. 2010. Involvement of Lgl and Mahjong/VprBP in Cell Competition. PLoS Biology.doi:10.1371/journal.pbio.1000422 (*equal contributing co-corresponding authors). (#18 in Discover magazine top 100 Stories of 2010)

Klusza S, Deng WM. 2010. poly is required for nurse-cell chromosome dispersal and oocyte polarity in Drosophila. Fly (Austin). 4(2): 128-36.

Yu J, Zheng Y, Dong J, Klusza S, Deng WM *, Pan D *. 2010. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Developmental Cell. 18(2): 288-99. (*equal contributing co-corresponding authors)


Shyu LF, Sun J, Chung HM, Huang YC, Deng WM. 2009. Notch signaling and developmental cell-cycle arrest in Drosophila polar follicle cells. Molecular Biology of the Cell 20(24): 5064-73.

Yatsenko AS, Kucherenko MM, Pantoja M, Fischer KA, Madeoy J, Deng WM, Schneider M, Baumgartner S, Akey J, Shcherbata HR, Ruohola-Baker H. 2009. The conserved WW-domain binding sites in Dystroglycan C-terminus are essential but partially redundant for Dystroglycan function. BMC Developmental Biology. 27: 9-18

Tian AG, Deng WM. 2009. Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes. Developmental Biology. 327(2): 458-64.

Cooper E, Deng WM, Chung HM. 2009. Aph-1 is required to regulate Presenilin-mediated gamma-secretase activity and cell survival in Drosophila wing development. Genesis. 47(3): 169-74.


Sun J, Smith L, Armento A, Deng WM. 2008. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. The Journal of Cell Biology. 182(5): 885-96.

Yu J, Poulton J, Huang YC, Deng WM. 2008. The Hippo Pathway Promotes Notch Signaling in Regulation of Cell Differentiation, Proliferation, and Oocyte Polarity. PLoS ONE. 3(3): e1761.

Tian AG, Deng WM. 2008. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development. 135(3):463-71.


Sun J, Deng WM. 2007. Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Developmental Cell. 12(3):431-42.


Schneider M, Khalil AA, Poulton J, Castillejo-Lopez C, Egger-Adam D, Wodarz A, Deng WM, Baumgartner S. 2006. Perlecan and Dystroglycan act at the basal side of the Drosophila follicular epithelium to maintain epithelial organization. Development. 133:3805-15.

Poulton J, Deng WM. 2006. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc Natl Acad Sci U S A. 103(34): 12775-80.


Sun J, Deng WM. 2005. Notch-dependent downregulation of the homeodomain gene cut is required for the mitotic cycle/endocycle switch and cell differentiation in Drosophila follicle cells. Development 132: 4299-4308.

Althauser C, Jordan K, Deng WM, Ruohola-Baker H. 2005. Fringe-dependent notch activation and tramtrack function are required for specification of the polar cells in Drosophila oogenesis. Developmental Dynamics 232: 1013-1020.

2004 and before

Schaeffer V., Althauser C., Shcherbata HR, Deng WM, Ruohola-Baker H. 2004. Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transtition in Drosophila follicle cells. Current Biology 14(7): 630-6.

Deng, W.M., M. Schneider, R.W. Frock, C. Castillejo-Lopez, S. Baumgartner, and H. Ruohola-Baker. 2003. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development 130: 173-184. (Cover Photograph).

Deng, W.M., C. Althauser, and H. Ruohola-Baker. 2001. Notch-Delta signaling induces a transition from mitotic cell cycle to endocycle in Drosophila follicle cells. Development 128: 4737-4746. (Cover Photograph).

Deng, W.M., and H. Ruohola-Baker. 2000. Laminin A is required for follicle cell-oocyte signaling that leads to establishment of the anterior-posterior axis in Drosophila. Current Biology 10: 683-686.

Jordan, K.C., N.J.Clegg, J.A. Blasi, A.M. Morimoto, J.Sen, D.Stein, H.McNeill, W.M. Deng, M. Tworoger, and H. Ruohola-Baker. 2000. The homeobox gene mirror links EGF signaling to embryonic dorso-ventral axis formation through notch activation.Nature Genetics 24: 429-433.

Larkin, M.K.,* W.M. Deng,* K. Holder, M. Tworoger, N. Clegg, and H. Ruohola-Baker. 1999. Role of Notch pathway in terminal follicle cell differentiation during Drosophila oogenesis. Development Genes & Evolution 209: 301-311. (*equal contribution)

Deng, W.M., K. Leaper, and M. Bownes. 1999. A targeted gene silencing technique show that Drosophila myosin VI is required for egg chamber and imaginal disc morphogenesis. Journal of Cell Science 112: 3677-3690.

Tzolovsky, G.,* W.M. Deng,* T. Schlitt, and M. Bownes. 1999. The Function of the broad complex during Drosophila melanogaster oogenesis. Genetics 153: 1371-1383. (*equal contribution)

Hicks, J.L., W.M. Deng, A.D. Rogat, K.G. Miller, and M. Bownes. 1999. Class VI unconventional myosin is required for spermatogenesis in Drosophila. Molecular Biology of the Cell 10: 4341-4353.

Deng, W.M., and M. Bownes. 1998. Patterning and morphogenesis of the follicle cell epithelium during Drosophila oogenesis. Molecular biology of the cell. 10(12): 441-552.

Deng, W.M., and M. Bownes. 1997. Two signaling pathways specify localised expression of the broad complex in Drosophila eggshell patterning and morphogenesis. Development 124: 4639-4647.

Deng, W.M., D. Zhao, K. Rothwell, and M. Bownes. 1997. Analysis of P[gal4] insertion lines of Drosophila melanogaster as a route to identifying genes important in the follicle cells during oogenesis. Molecular Human Reproduction 5: 101-110.

Deng, W.M., and D. Zhao. 1994. Multiple expressions and functions of developmental regulatory genes. Chinese Journal of Cell Biology 14: 164-171.

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