PCB 4673 Course Outline I. THE DISCOVERY OF EVOLUTION A. The Early Development of Evolutionary Biology B. Charles Darwin and His Contributions C. The Merger of Mendelism and Darwinism II. THE AGENTS OF EVOLUTION A. Producing Genetic Variation 1. Genotype, Environment, and Phenotype 2. Generating Variation in Gene Pools 3. Fundamental Population Genetics B. Molding Genetic Variation 1. Natural Selection 2. Response to Selection in Large Populations 3. Random Processes in Finite Populations 4. Selection and Response in Finite Populations C. The Formation and Reconstruction of Lineages 1. Divergence Between Populations 2. Evolution of Reproductive Isolation 3. Inferring Evolutionary Relationships III. THE EVOLUTION OF DIVERSITY A. The History of Diversity 1. The Tree of Life 2. The Major Radiations 3. Patterns in the Rise and Fall of Clades B. Patterns of Phenotypic Diversity 1. Patterns of Character Evolution 2. Behavioral Diversity 3. Molecular Evolution IV. THE APPLICATIONS OF EVOLUTIONARY BIOLOGY A. Reinterpreting Disease B. Managing Nature